Evidence map›Paper›PMID 31907784›Full record

ReviewJournal of cardiovascular translational research2020

Infarct Zone: a Novel Platform for Exosome Trade in Cardiac Tissue Regeneration.

Finosh G Thankam, Devendra K Agrawal

Open access · greenAbstract readReview
In one paragraph

Review in Journal of cardiovascular translational research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
1.7field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 29 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Expression ofGenes · 2024
    Article
  5. Review
  6. Review
  7. Extracellular vesicles as personalized medicine.Molecular aspects of medicine · 2023
    Review
  8. Review
  9. Article
  10. Peripheral Nerve Regeneration: Opportunities and Challenges.Journal of spine research and surgery · 2023
    Article
  11. Review
  12. Article
  13. Review
  14. Article
  15. Article
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Finosh G ThankamDepartment of Translational Research, Western University of Health Sciences, 309 E. Second Street, Pomona, CA, 91766, USA.ORCID 0000-0001-7285-9808
Devendra K AgrawalDepartment of Translational Research, Western University of Health Sciences, 309 E. Second Street, Pomona, CA, 91766, USA. DAgrawal@WesternU.edu.ORCID 0000-0001-5445-0013
Western University of Health Sciences · US

Funding

GENE AND STEM CELL THERAPY IN CORONARY ARTERY BYPASS GRAFTR01HL128063 · NHLBI · CREIGHTON UNIVERSITY · PI AGRAWAL, DEVENDRA K. · 2015 to 2018
$2.9M
Novel Approach to Stabilize Atherosclerotic Plaque in Carotid ArteryR01HL144125 · NHLBI · WESTERN UNIVERSITY OF HEALTH SCIENCES · PI AGRAWAL, DEVENDRA K. · 2018 to 2021
$2.8M
Novel Molecular Target to Prevent Maturation Failure of Arteriovenous FistulaR01HL147662 · NHLBI · WESTERN UNIVERSITY OF HEALTH SCIENCES · PI AGRAWAL, DEVENDRA K. · 2019 to 2022
$2.8M
NHLBI NIH HHS R01 HL128063NHLBI NIH HHS R01 HL144125NHLBI NIH HHS R01 HL147662
6 · The paper itself

Abstract

The global incidence of coronary artery diseases (CADs), especially myocardial infarction (MI), has drastically increased in recent years. Even though the conventional therapies have improved the outcomes, the post-MI complications and the increased rate of recurrence among the survivors are still alarming. Molecular events associated with the pathogenesis and the adaptive responses of the surviving myocardium are largely unknown. Focus on exosome-mediated signaling for cell-cell/matrix communications at the infarct zone reflects an emerging opportunity in cardiac regeneration. Also, cardiac tissue engineering provides promising insights for the next generation of therapeutic approaches in the management of CADs. In this article, we critically reviewed the current understanding on the biology of cardiac exosomes, therapeutic potential of exosomes, and recent developments in cardiac tissue engineering and discussed novel translational approaches based on tissue engineering and exosomes for cardiac regeneration and CADs.

Indexed as

RegenerationRegenerative MedicineTissue EngineeringAnimalsExosomesHumansMyocardial InfarctionMyocardiumRecovery of FunctionCardiosomesExosomesExtracellular vesiclesInfarct zoneMyocardial infarctionTissue engineering

Identifiers

PMID31907784
PMCPMC7335685
OpenAlexW3000703151

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.