Evidence map›Paper›PMID 31907774›Full record

Trial reportDigestive diseases and sciences2020

Home-Based Physical Activity and Diet Intervention to Improve Physical Function in Advanced Liver Disease: A Randomized Pilot Trial.

Hui Wei Chen, Arny Ferrando, Michelle G White, Richard A Dennis, Jesse Xie, Margaret Pauly, Sanghee Park, Thaddeus Bartter, Michael A Dunn, Astrid Ruiz-Margain and 2 more

Registry-linked trialAbstract readRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in Digestive diseases and sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06149026 (Comparison of the Effect of Two Interventions on Liver Frailty Index in Pre-frail and Frail Cirrhotic Patients Enlisted for Liver Transplantation), which is not on this map. Cited by 51 papers, 9 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
51citing papers in PubMed, 9 pooled it
6.1field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06149026 naunknown statusnot on this mapstarted 2023, after this paper: background citation

Comparison of the Effect of Two Interventions on Liver Frailty Index in Pre-frail and Frail Cirrhotic Patients Enlisted for Liver Transplantation

TypeinterventionalSponsorPontificia Universidad Catolica de ChileRan2023 to 2023Enrolled80ConditionsCirrhosis, LiverArmsPhysical and nutritional therapy
3 · Its place in the literature

Who cites it

51 citing papers in PubMed, 9 syntheses or guidelines pooled it, 89 citations in OpenAlex.

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  8. Physical Effects, Safety and Feasibility of Prehabilitation in Patients Awaiting Orthotopic Liver Transplantation, a Systematic Review.Transplant international : official journal of the European Society for Organ Transplantation · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 6 institutions in 2 countries.

Hui Wei ChenDivision of Gastroenterology, Hepatology and Nutrition, Thomas E. Starzl Transplantation Institute, University of Pittsburgh Medical Center, 3471 Fifth Avenue, Suite 201, Pittsburgh, PA, 15213, USA.
Arny FerrandoDepartment of Geriatrics, Donald W. Reynolds Institute on Aging, University of Arkansas for Medical Sciences, Little Rock, AR, USA.
Michelle G WhiteDivision of Gastroenterology and Hepatology, University of Arkansas for Medical Sciences, Little Rock, AR, USA.
Richard A DennisDepartment of Geriatrics, Donald W. Reynolds Institute on Aging, University of Arkansas for Medical Sciences, Little Rock, AR, USA.
Jesse XieDivision of Gastroenterology and Hepatology, University of Arkansas for Medical Sciences, Little Rock, AR, USA.
Margaret PaulyLiver Transplant Program, University of Arkansas for Medical Sciences, Little Rock, AR, USA.
Sanghee ParkDepartment of Geriatrics, Donald W. Reynolds Institute on Aging, University of Arkansas for Medical Sciences, Little Rock, AR, USA.
Thaddeus BartterDivision of Pulmonary Medicine, University of Arkansas for Medical Sciences, Little Rock, AR, USA.
Michael A DunnDivision of Gastroenterology, Hepatology and Nutrition, Thomas E. Starzl Transplantation Institute, University of Pittsburgh Medical Center, 3471 Fifth Avenue, Suite 201, Pittsburgh, PA, 15213, USA.
Astrid Ruiz-MargainDepartment of Gastroenterology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico.
W Ray KimDivision of Gastroenterology and Hepatology, Stanford University, Palo Alto, CA, USA.
Andres Duarte-RojoDivision of Gastroenterology, Hepatology and Nutrition, Thomas E. Starzl Transplantation Institute, University of Pittsburgh Medical Center, 3471 Fifth Avenue, Suite 201, Pittsburgh, PA, 15213, USA. duarterojoa@upmc.edu.ORCID 0000-0002-5377-9295
University of Arkansas for Medical Sciences · USUniversity of Pittsburgh Medical Center · USInstitute on Aging · USCentral Arkansas Veterans Healthcare System · USInstituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán · MXStanford University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionA decline in physical function is highly prevalent and a poor prognostic factor in cirrhosis. We assessed the benefits of a home-based physical activity program (HB-PAP) in patients with cirrhosis with a randomized pilot trial.

methodsAll participants received a personal activity tracker to monitor daily activities and were given 12 g/day of an essential amino acid supplement. The HB-PAP intervention consisted of biweekly counseling sessions to increase physical activity for 12 weeks. Six-minute walk test (6MWT) and cardiopulmonary exercise testing (CPET) assessed changes in aerobic fitness. Different anthropometric measuring tools were used for skeletal muscle and adiposity assessment.

resultsSeventeen patients (60% male; 29% nonalcoholic steatohepatitis/cryptogenic, 29% hepatitis C, 24% alcohol, 18% other) were randomized, 9 to HB-PAP group. There were no significant differences in MELD-sodium between HB-PAP and controls at baseline or after the 12-week intervention. By the end of study, there was a significant between-group difference in daily step count favoring the active group (2627 [992-4262], p = 0.001), with less sedentary patients in the active group (33-17% vs. 25-43%, p = 0.003). The 6MWT improved in the HB-PAP group (423 ± 26 m vs. 482 ± 35 m), while the controls had a nonsignificant drop (418 ± 26 m vs. 327 ± 74 m) with a significant between-group difference. CPET did not change. Other than an improvement in psoas muscle index, there were no differences in anthropometry, or in quality of life.

conclusionsHB-PAP maintained physical performance and improved aerobic fitness according to 6MWT but not CPET, supporting the use of personal activity trackers to monitor/guide home-based prehabilitation programs in cirrhosis.

Indexed as

Exercise TherapyHome Care ServicesAdultAgedAnthropometryArkansasBiopsyExercise TestFemaleHumansLiver CirrhosisMaleMiddle AgedPilot ProjectsPrognosisQuality of LifeExerciseFrailtyPrehabilitationSarcopenia

Identifiers

PMID31907774
OpenAlexW3000031034

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.