Evidence map›Paper›PMID 31907759›Full record

ArticleCanadian journal of public health = Revue canadienne de sante publique2020

Pulse oximetry screening for critical congenital heart defects in Ontario, Canada: a cost-effectiveness analysis.

Amit Mukerji, Amy Shafey, Amish Jain, Eyal Cohen, Prakesh S Shah, Beate Sander, Vibhuti Shah

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Canadian journal of public health = Revue canadienne de sante publique, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  3. Article
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  5. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Amit MukerjiDepartment of Pediatrics, McMaster University, Hamilton, ON, Canada. mukerji@mcmaster.ca.
Amy ShafeyDepartment of Pediatrics, University of Calgary, Calgary, AB, Canada.
Amish JainDepartment of Pediatrics, University of Toronto, Toronto, ON, Canada.
Eyal CohenDepartment of Pediatrics, University of Toronto, Toronto, ON, Canada.
Prakesh S ShahDepartment of Pediatrics, University of Toronto, Toronto, ON, Canada.
Beate SanderInstitute of Health Policy, Management and Evaluation, University of Toronto, Toronto, ON, Canada.
Vibhuti ShahDepartment of Pediatrics, University of Toronto, Toronto, ON, Canada.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivePreviously conducted cost-effectiveness analyses of pulse oximetry screening (POS) for critical congenital heart defects (CCHDs) have shown it to be a cost-effective endeavour, but the geographical setting of Ontario in relation to its vast yet sparsely populated regions presents unique challenges. The objective of this study was to estimate the cost-effectiveness of POS for CCHD in Ontario, Canada.

methodsA cost-effectiveness analysis, comparing POS to no POS, was conducted from the Ontario healthcare payer perspective using a Markov model. The base case was defined as a well-appearing newborn at 24 h of age. Outcome measures, including quality-adjusted life months (QALMs), lifetime costs, and incremental cost-effectiveness ratios (ICER) [ΔCost/ΔQALMs], were calculated over a lifetime horizon. All outcomes were discounted at 1.5% per year. Cost-effectiveness was assessed using an a priori ICER threshold of CAD$4166.67 per QALM (equivalent to CAD$50,000 per quality-adjusted life year). Deterministic and probabilistic sensitivity analyses were conducted to assess parameter uncertainty.

resultsImplementation of POS is expected to lead to timely diagnosis of 51 CCHD cases annually. The incremental cost of performing POS was estimated to be $27.27 per screened individual, with a gain of 0.02455 QALMs. This yielded an ICER of CAD$1110.79 per QALM, well below the pre-determined threshold. The probabilistic sensitivity analysis estimated a 92.3% chance of routine implementation of POS being cost-effective.

conclusionRoutine implementation of POS for CCHD in Ontario is expected to be cost-effective.

Indexed as

Heart Defects, CongenitalNeonatal ScreeningOximetryCost-Benefit AnalysisHumansInfant, NewbornOntarioCost-effectiveness thresholdCost-utility analysisHealth economicsSaturation screeningUtility

Identifiers

PMID31907759
PMCPMC7501328

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.