Evidence map›Paper›PMID 31907584›Full record

ArticleNaunyn-Schmiedeberg's archives of pharmacology2020

Evaluation of histophysiological alterations associated with ketoprofen administration in albino NMRI mice.

Alina Paunescu, Cristina Maria Ponepal, Magdalena Cristina Zagardan, Cristina Florentina Plesa, Roxana Maria Nemes, Camelia Nicolae, Alina Bisoc, Magdalena Diaconu, Irina Fierascu, Radu Claudiu Fierascu and 2 more

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In one paragraph

Article in Naunyn-Schmiedeberg's archives of pharmacology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Alina PaunescuFaculty of Sciences, Physical Education and Informatics, University of Pitesti, 1 Târgu din Vale Str, 110040, Pitesti, Romania.
Cristina Maria PonepalFaculty of Sciences, Physical Education and Informatics, University of Pitesti, 1 Târgu din Vale Str, 110040, Pitesti, Romania.
Magdalena Cristina ZagardanFaculty of Sciences, Physical Education and Informatics, University of Pitesti, 1 Târgu din Vale Str, 110040, Pitesti, Romania.
Cristina Florentina PlesaFaculty of Medicine, Titu Maiorescu University of Bucharest, 22 Dâmbovnicului Street, Bucharest, Romania.
Roxana Maria NemesFaculty of Medicine, Titu Maiorescu University of Bucharest, 22 Dâmbovnicului Street, Bucharest, Romania.
Camelia NicolaeCarol Davila University of Medicine and Pharmacy, 8 Eroii Sanitari Blvd, 050474, Bucharest, Romania.
Alina BisocFaculty of Medicine, Transilvania University of Brasov, 29 Eroilor Blvd, 500036, Brașov, Romania.
Magdalena DiaconuUniversity of Medicine and Pharmacy Craiova, 2 Petru Rareș St, 200349, Craiova, Romania.
Irina FierascuNational Research and Development Institute for Chemistry and Petrochemistry, ICECHIM, 202 Spl. Independentei, 060021, Bucharest, Romania. dumitriu.irina@yahoo.com.ORCID 0000-0002-1834-9812
Radu Claudiu FierascuNational Research and Development Institute for Chemistry and Petrochemistry, ICECHIM, 202 Spl. Independentei, 060021, Bucharest, Romania.
Monica Marilena TantuFaculty of Sciences, Physical Education and Informatics, University of Pitesti, 1 Târgu din Vale Str, 110040, Pitesti, Romania.
Cristina Liliana SoareFaculty of Sciences, Physical Education and Informatics, University of Pitesti, 1 Târgu din Vale Str, 110040, Pitesti, Romania.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The aim of this study was to investigate the changes caused by the administration of ketoprofen to albino NMRI mice on some hematological, biochemical, and structural parameters. For this purpose, the mice were divided into two lots: a control batch and an experimental batch to which ketoprofen was administered subcutaneously at a dose of 10 mg/kg body weight per day for 7 days. A decrease in erythrocyte number and hemoglobin was observed altogether with the increase in white blood cells. Blood biochemistry indicates increased blood glucose, cholesterol, and triglyceride levels. Enzyme values (AST, ALT, and ALP) show a significant increase. Hepatic pathology reveals the enlargement of sinusoidal capillaries, the presence of leukocyte infiltrates associated with necrosis zones.

Indexed as

AnimalsChemical and Drug Induced Liver InjuryKetoprofenLiverMaleMiceKetoprofenBiochemical and hematological parametersKetoprofenLiver histopathologyMice

Identifiers

PMID31907584

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.