ArticleClinical infectious diseases : an official publication of the Infectious Diseases Society of America2020
Bacterial Infections Associated With Substance Use Disorders, Large Cohort of United States Hospitals, 2012-2017.
Article in Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 86 papers, 2 of them syntheses that pooled it.
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Who cites it
86 citing papers in PubMed, 2 syntheses or guidelines pooled it, 126 citations in OpenAlex.
- Evidence-based framework for identifying opioid use disorder in administrative data: A systematic review and methodological development study.Pain medicine (Malden, Mass.) · 2026Pooled it
- Infectious Diseases Among People Experiencing Homelessness: A Systematic Review of the Literature in the United States and Canada, 2003-2022.Public health reports (Washington, D.C. : 1974)Pooled it
- Dalba Got Back? Use of Dalbavancin for the Treatment of Vertebral Osteomyelitis.Open forum infectious diseases · 2024Trial
- Real-world comparative effects of slow-release oral morphine vs. methadone on healthcare use for opioid use disorder: A population-based target trial emulation.Addiction (Abingdon, England) · 2026Article
- Association Between Hospital-Based Addiction Consult Service Implementation and Hospital Length-of-Stay and 30-Day Readmission Rates for Patients with Opioid Use Disorder.Journal of general internal medicine · 2026Article
- Organizational perspectives on barriers and facilitators to an integrated care model for opioid use disorder and serious injection-related infections.Journal of substance use and addiction treatment · 2026Article
- Tricuspid Valve Infective Endocarditis in People Who Inject Drugs: A Single-Center Retrospective Observational Study of Percutaneous Mechanical Aspiration and a Surgical Approach.Infectious disease reports · 2026Article
- Missed opportunities for Hepatitis C Virus screening and care among persons hospitalized for injection-related infections.Drug and alcohol dependence · 2026Article
- Failure to Treat Opioid Use Disorder and Opioid Withdrawal Associated with Patient-Directed Discharge in People with Injection-Related Infections.Journal of general internal medicine · 2026Article
- Burden of Injection Drug Use-Related Infection Hospitalizations in Tennessee, 2016-2023.Open forum infectious diseases · 2026Article
- Trends in sepsis-related mortality due to dermatologic infections in the United States: Demographic and geographic patterns from 1999 to 2023.Journal of public health research · 2026Article
- Article
- Integrated infectious disease and substance use disorder treatment for severe injection-related infections: protocol for the randomized controlled HI-SIRI trial.Addiction science & clinical practice · 2026Article
- Improving hospital-based care for patients with injection-drug related infections: provider perspectives.Addiction science & clinical practice · 2026Article
- Health, Costs, and Injection-Related Infections at a Hypothetical Overdose Prevention Center.JAMA network open · 2026Article
- Qualitative analysis of barriers and facilitators to healthcare engagement for people with injecting-related invasive infections using a social ecological framework.Addiction (Abingdon, England) · 2025Article
- Clinical Impact of an Expanded MOUD Access Initiative for Patients Hospitalized With Infections From Intravenous Opioid Use.American journal of medicine open · 2025Article
- Candida Right-Sided Infective Endocarditis.Cureus · 2025Article
- Infectious Diseases in People Who Use Drugs Introduction.Open forum infectious diseases · 2025Article
- Bacterial and fungal infections in persons who inject drugs.Clinical microbiology reviews · 2025Review
26 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
backgroundRises in the incidence of bacterial infections, such as infective endocarditis (IE), have been reported in conjunction with the opioid crisis. However, recent trends for IE and other serious infections among persons with substance use disorders (SUDs) are unknown.
methodsUsing the Premier Healthcare Database, we identified hospitalizations from 2012 through 2017 among adults with primary discharge diagnoses of bacterial infections and secondary SUD diagnoses, using International Classification of Diseases, Clinical Modification Ninth and Tenth Revision codes. We calculated annual rates of infections with SUD diagnoses and evaluated temporal trends. Blood and cardiac tissue specimens were identified from IE hospitalizations to describe the microbiology distribution and temporal trends among hospitalizations with and without SUDs.
resultsAmong 72 481 weighted IE admissions recorded, SUD diagnoses increased from 19.9% in 2012 to 39.4% in 2017 (P < .0001). Hospitalizations with SUDs increased from 1.1 to 2.1 per 100 000 persons for IE, 1.4 to 2.4 per 100 000 persons for osteomyelitis, 0.5 to 0.9 per 100 000 persons for central nervous system abscesses, and 24.4 to 32.9 per 100 000 persons for skin and soft tissue infections. For adults aged 18-44 years, IE-SUD hospitalizations more than doubled, from 1.6 in 2012 to 3.6 in 2017 per 100 000 persons. Among all IE-SUD hospitalizations, 50.3% had a Staphylococcus aureus infection, compared with 19.4% of IE hospitalizations without SUDs.
conclusionsRates of hospitalization for serious infections among persons with SUDs are increasing, driven primarily by younger age groups. The differences in the microbiology of IE hospitalizations suggest that SUDs are changing the epidemiology of these infections.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.