ArticleNature neuroscience2020
Breakdown of spatial coding and interneuron synchronization in epileptic mice.
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Article in Nature neuroscience, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 132 papers.
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132citing papers in PubMed
14.4field-weighted citation impact, top 1% of its field
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Who cites it
132 citing papers in PubMed, 207 citations in OpenAlex.
- Single-nucleus transcriptomics reveals cell type-specific remodeling and epilepsy-associated microglia.iScience · 2026Article
- Miniscope Zero: a fully wireless, single-cell-resolution miniature microscope for imaging neural dynamics in freely behaving animals.bioRxiv : the preprint server for biology · 2026Article
- Clustered inputs engage dendritic nonlinearities and calcium signaling to support efficient place-field formation in CA1 pyramidal neurons.Cell reports · 2026Article
- Unique deficits in place coding across subfields of the hippocampus in a mouse model of temporal lobe epilepsy.Epilepsia · 2026Article
- Medial entorhinal-hippocampal desynchronization parallels the emergence of memory impairment in a mouse model of Alzheimer's disease pathology.Cell reports · 2026Article
- Article
- Evaluating place cell detection methods in Rats and Humans: Implications for cross-species spatial coding.PLoS computational biology · 2026Article
- Single-Nucleus Transcriptomics Reveals Cell Type-Specific Remodeling and Epilepsy-Associated Microglia.bioRxiv : the preprint server for biology · 2026Article
- MiniFAST: a sensitive and fast miniaturized microscope forNeurophotonics · 2026Article
- Miniaturized widefield microscope for high speed in vivo voltage imaging.Biomedical optics express · 2026Article
- Induced epileptic seizures in larval zebrafish reveal a synaptic modulation associated with the post-ictal state.Brain communications · 2026Article
- Dissecting neuronal circuit function and dysfunction in Alzheimer's disease mouse models: from conventional calcium imaging analysis to machine learning-based approaches.Frontiers in aging neuroscience · 2026Review
- Pentylenetetrazole kindling impairs place recognition memory associated with suppressing proBDNF-mediated neural information flows at the hippocampal CA3-CA1 synapses.Frontiers in pharmacology · 2026Article
- UNIQUE DEFICITS IN PLACE CODING ACROSS SUBFIELDS OF THE HIPPOCAMPUS IN A MOUSE MODEL OF TEMPORAL LOBE EPILEPSY.bioRxiv : the preprint server for biology · 2025Article
- Thermodynamic Biomarkers of Neuroinflammation: Nanothermometry, Energy-Stress Dynamics, and Predictive Entropy in Glial-Vascular Networks.International journal of molecular sciences · 2025Review
- Bridging single cells to organs: Mesoscale modules as fundamental units of tissue function.Cell · 2025Review
- Hippocampal Interneurons Shape Spatial Coding Alterations in Neurological Disorders.Molecular neurobiology · 2025Review
- Behavioral Timing of Interictal Spikes, But Not Rate, Correlates with Impaired Working Memory Performance.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Interneuron theta phase locking controls seizure susceptibility.bioRxiv : the preprint server for biology · 2025Article
- Integrating optical neuroscience tools into touchscreen operant systems.Nature protocols · 2025Review
72 more citing papers are in PubMed but not listed here.
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Authors and funding
27 authors at 7 institutions in 3 countries.
Tristan Shuman *Nash Family Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, USA. tristan.shuman@mssm.edu.ORCID http://orcid.org/0000-0003-2310-6142
Daniel Aharoni *Department of Neurology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA.ORCID http://orcid.org/0000-0003-4931-8514
Denise J Cai *Nash Family Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Christopher R LeeNash Family Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID http://orcid.org/0000-0002-5952-9924
Spyridon ChavlisInstitute of Molecular Biology and Biotechnology (IMBB), Foundation for Research and Technology Hellas (FORTH), Heraklion, Greece.ORCID http://orcid.org/0000-0002-1046-1201
Lucia Page-HarleyNash Family Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Lauren M VetereNash Family Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Yu FengNash Family Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Chen Yi YangDepartment of Neurology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA.
Irene Mollinedo-GajateDepartment of Neurology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA.
Lingxuan ChenNash Family Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Zachary T PenningtonNash Family Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Jiannis TaxidisDepartment of Neurology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA.
Sergio E FloresDepartment of Neurology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA.
Kevin ChengDepartment of Neurology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA.
Milad JavaherianDepartment of Neurology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA.ORCID http://orcid.org/0000-0002-1254-2996
Christina C KabaDepartment of Neurology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA.
Naina RaoDepartment of Neurology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA.
Mimi La-VuDepartment of Neurobiology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA.
Ioanna PandiInstitute of Molecular Biology and Biotechnology (IMBB), Foundation for Research and Technology Hellas (FORTH), Heraklion, Greece.
Matthew ShtrahmanDepartment of Neurosciences, University of California, San Diego, La Jolla, CA, USA.
Konstantin I BakhurinDepartment of Neurobiology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA.
Sotiris C MasmanidisDepartment of Neurobiology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA.ORCID http://orcid.org/0000-0002-8699-3335
Baljit S KhakhDepartment of Physiology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA.
Panayiota PoiraziInstitute of Molecular Biology and Biotechnology (IMBB), Foundation for Research and Technology Hellas (FORTH), Heraklion, Greece. poirazi@imbb.forth.gr.ORCID http://orcid.org/0000-0001-6152-595X
Alcino J SilvaIntegrative Center for Learning and Memory, University of California, Los Angeles, Los Angeles, CA, USA.
Peyman GolshaniDepartment of Neurology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA. pgolshani@mednet.ucla.edu.ORCID http://orcid.org/0000-0002-5406-7695
University of California, Los Angeles · USIcahn School of Medicine at Mount Sinai · USFORTH Institute of Molecular Biology and Biotechnology · GRFoundation for Research and Technology Hellas · GRUniversity of California San Diego · USUniversity of Crete · GRWest Los Angeles College · US
Funding
UCLA Center for Translational Research in Neurodevelopment: UC-TRaNU54HD087101 · NICHD · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI MCCRACKEN, JAMES T. · 2016 to 2020
$6.5MTraining Grant in Neurobehavioral GeneticsT32NS048004 · NINDS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI BEARDEN, CARRIE E, OPHOFF, ROEL A · 2004 to 2025
$5.8MMolecular, Cellular and Circuit Mechanisms for Age-Related Deficits in Memory-LinkingRF1AG013622 · NIA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI SILVA, ALCINO J. · 2017 to 2022
$4.9MAstrocyte branchlet dysfunction as an early step in brain disordersDP1MH104069 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI KHAKH, BALJIT · 2013 to 2017
$3.9MCCR5 Activation and Cognitive Dysfunction Caused by HIV-ProteinsR01NS106969 · NINDS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI SILVA, ALCINO J. · 2017 to 2021
$3.7MResearch Training in the Neuroscience of AgingT32AG049688 · NIA · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI Joseph Michael Castellano, PATRICK R HOF · 2015 to 2026
$3.0MBuilding and sharing next generation open-source, wireless, multichannel miniaturized microsopes for imaging activity in freely behaving miceU01NS094286 · NINDS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI GOLSHANI, PEYMAN, KHAKH, BALJIT · 2015 to 2017
$2.7MHow does the brain maximize storage capacity?DP2MH122399 · NIMH · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI CAI, DENISE JADE · 2019 to 2020
$2.6MTraining Program in Neural MicrocircuitsT32NS058280 · NINDS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI FELDMAN, JACK L · 2007 to 2017
$2.4MInhibitory neuron circuit organization and function in prefrontal cortex.R01MH105427 · NIMH · UNIVERSITY OF CALIFORNIA-IRVINE · PI GOLSHANI, PEYMAN, XU, XIANGMIN · 2015 to 2019
$2.3MMolecular, Cellular and Circuit Mechnisms for Memory-linking deficits in Psychiatric DisordersR01MH113071 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI SILVA, ALCINO J. · 2017 to 2021
$2.3MEpilepsy related cell loss and cognitive dysfunctionR01NS099137 · NINDS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI GOLSHANI, PEYMAN, HOUSER, CAROLYN R · 2017 to 2021
$2.1MBLRD VA I01 BX001524BLRD VA I01 BX005202NIA NIH HHS RF1 AG013622NIA NIH HHS T32 AG049688NICHD NIH HHS U54 HD087101NIMH NIH HHS DP1 MH104069NIMH NIH HHS DP2 MH122399NIMH NIH HHS F32 MH097413NIMH NIH HHS R01 MH101198NIMH NIH HHS R01 MH105427NIMH NIH HHS R01 MH113071NIMH NIH HHS T32 MH015795NINDS NIH HHS K08 NS093130NINDS NIH HHS R01 NS099137NINDS NIH HHS R01 NS106969NINDS NIH HHS R03 NS111493NINDS NIH HHS T32 NS048004NINDS NIH HHS T32 NS058280NINDS NIH HHS U01 NS094286
Abstract
Temporal lobe epilepsy causes severe cognitive deficits, but the circuit mechanisms remain unknown. Interneuron death and reorganization during epileptogenesis may disrupt the synchrony of hippocampal inhibition. To test this, we simultaneously recorded from the CA1 and dentate gyrus in pilocarpine-treated epileptic mice with silicon probes during head-fixed virtual navigation. We found desynchronized interneuron firing between the CA1 and dentate gyrus in epileptic mice. Since hippocampal interneurons control information processing, we tested whether CA1 spatial coding was altered in this desynchronized circuit, using a novel wire-free miniscope. We found that CA1 place cells in epileptic mice were unstable and completely remapped across a week. This spatial instability emerged around 6 weeks after status epilepticus, well after the onset of chronic seizures and interneuron death. Finally, CA1 network modeling showed that desynchronized inputs can impair the precision and stability of CA1 place cells. Together, these results demonstrate that temporally precise intrahippocampal communication is critical for spatial processing.
Indexed as
AnimalsCA1 Region, HippocampalDentate GyrusEpilepsy, Temporal LobeInterneuronsMaleMiceMice, Inbred C57BLNeural Pathways
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