ArticleJournal of perinatology : official journal of the California Perinatal Association2020
Extreme neonatal hyperbilirubinemia and kernicterus spectrum disorder in Denmark during the years 2000-2015.
Article in Journal of perinatology : official journal of the California Perinatal Association, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 2 of them syntheses that pooled it.
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Who cites it
18 citing papers in PubMed, 2 syntheses or guidelines pooled it, 54 citations in OpenAlex.
- [Guidelines for the diagnosis and treatment of common neonatal diseases in primary healthcare institutions: neonatal jaundice (2025)].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2025Guideline
- Zinc sulfate on neonatal hyperbilirubinemia: an updated systematic review and meta-analysis.European journal of pediatrics · 2024Pooled it
- Action spectrum of phototherapy in hyperbilirubinemic neonates.Pediatric research · 2022Trial
- Assessment, management, and incidence of neonatal jaundice in healthy neonates cared for in primary care: a prospective cohort study.Scientific reports · 2022Trial
- Effect of blue LED phototherapy centered at 478 nm versus 459 nm in hyperbilirubinemic neonates: a randomized study.Pediatric research · 2021Trial
- Home and in-hospital phototherapy as comparable select routine approach for neonatal hyperbilirubinemia.Pediatric research · 2026Article
- Development and Validation of a Prenatal Prediction Model for Neonatal Hyperbilirubinemia Based on Maternal Factors: Revealing Heterogeneous Risk Profiles Across Gestational Age Subgroups.International journal of women's health · 2026Article
- Neonatal hyperbilirubinemia: past lessons, current practices, and future directions.European journal of pediatrics · 2025Review
- Trends of extreme hyperbilirubinemia related infant mortality in select European countries (1990-2019).Pediatric research · 2025Article
- Modified Kramer's versus Kramer's Method for Clinical Assessment of Jaundice in Term and Near-Term Neonates.Indian journal of pediatrics · 2025Article
- Controversies in our understanding of extreme hyperbilirubinemia in glucose-6-phosphate dehydrogenase-deficient neonates.Pediatric research · 2025Review
- Predictive and diagnostic measures for kernicterus spectrum disorder: a prospective cohort study.Pediatric research · 2024Article
- Article
- Laboratory Monitoring of Mother, Fetus, and Newborn in Hemolytic Disease of Fetus and Newborn.Transfusion medicine and hemotherapy : offizielles Organ der Deutschen Gesellschaft fur Transfusionsmedizin und Immunhamatologie · 2021Review
- Screening methods for neonatal hyperbilirubinemia: benefits, limitations, requirements, and novel developments.Pediatric research · 2021Review
- Prediction of ABO hemolytic disease of the newborn using pre- and perinatal quantification of maternal anti-A/anti-B IgG titer.Pediatric research · 2021Article
- The application of magnetic resonance imaging and diffusion-weighted imaging in the diagnosis of hypoxic-ischemic encephalopathy and kernicterus in premature infants.Translational pediatrics · 2021Article
- TcB, FFR, phototherapy and the persistent occurrence of kernicterus spectrum disorder.Journal of perinatology : official journal of the California Perinatal Association · 2020Article
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo determine the incidence and etiology of extreme neonatal hyperbilirubinemia, defined as total serum bilirubin (TSB) ≥450 µmol/L, and kernicterus spectrum disorder (KSD) in Denmark between 2000 and 2015. STUDY
designWe identified all infants born between 01.01.2000 and 31.12.2015 with TSB ≥450 µmol/L, ratio of conjugated to TSB <0.30, gestational age ≥35 weeks, and postnatal age ≤4 weeks, using Danish hospitals' laboratory databases.
resultWe included 408 infants. The incidence of extreme neonatal hyperbilirubinemia among infants with gestational age ≥35 weeks was 42/100,000 during the study period with a seemingly decreasing incidence between 2005 and 2015. Twelve of the 408 infants developed KSD, (incidence 1.2/100,000) Blood type ABO isohemolytic disease was the most common explanatory etiology.
conclusionsOur study stresses the importance of a systematic approach to neonatal jaundice and ongoing surveillance of extreme neonatal hyperbilirubinemia and KSD.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.