ArticleNature ecology & evolution2020
Nodal paralogues underlie distinct mechanisms for visceral left-right asymmetry in reptiles and mammals.
Article in Nature ecology & evolution, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 35 citations in OpenAlex.
- Genomic evolution of EGF-CFC genes in deuterostomes.Developmental dynamics : an official publication of the American Association of Anatomists · 2025Article
- Molecular anatomy of emerging Xenopus left-right organizer at successive developmental stages.Developmental dynamics : an official publication of the American Association of Anatomists · 2025Article
- Enigmatic Nodal and Lefty gene repertoire discrepancy: Latent evolutionary history revealed by vertebrate-wide phylogeny.Developmental dynamics : an official publication of the American Association of Anatomists · 2025Review
- CIROZ is dispensable in ancestral vertebrates but essential for left-right patterning in humans.American journal of human genetics · 2025Article
- Left-right symmetry breaking: learning from the chicken.Frontiers in cell and developmental biology · 2025Review
- Article
- Decrypting the phylogenetics history of EGF-CFC proteins Cripto and Cryptic.bioRxiv : the preprint server for biology · 2024Article
- Myosin1G promotes Nodal signaling to control zebrafish left-right asymmetry.Nature communications · 2024Article
- ETV2 induces endothelial, but not hematopoietic, lineage specification in birds.Life science alliance · 2024Article
- Function of nodal cilia in left-right determination: Mechanical regulation in initiation of symmetry breaking.Biophysics and physicobiology · 2024Review
- Morphological changes and twoFrontiers in cell and developmental biology · 2023Article
- Understanding laterality disorders and the left-right organizer: Insights from zebrafish.Frontiers in cell and developmental biology · 2022Review
- Abnormal left-right organizer and laterality defects in Xenopus embryos after formin inhibitor SMIFH2 treatment.PloS one · 2022Article
- Discovery of a genetic module essential for assigning left-right asymmetry in humans and ancestral vertebrates.Nature genetics · 2022Article
- Left-right asymmetric expression of theFrontiers in cell and developmental biology · 2022Article
- Nodal asymmetry and hedgehog signaling during vertebrate left-right symmetry breaking.Frontiers in cell and developmental biology · 2022Article
- Article
- The twists and turns of left-right asymmetric gut morphogenesis.Development (Cambridge, England) · 2020Review
- Molecular and cellular basis of left-right asymmetry in vertebrates.Proceedings of the Japan Academy. Series B, Physical and biological sciences · 2020Review
- Diversity of left-right symmetry breaking strategy in animals.F1000Research · 2020Review
Corrections and comments
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Authors and funding
12 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Unidirectional fluid flow generated by motile cilia at the left-right organizer (LRO) breaks left-right (L-R) symmetry during early embryogenesis in mouse, frog and zebrafish. The chick embryo, however, does not require motile cilia for L-R symmetry breaking. The diversity of mechanisms for L-R symmetry breaking among vertebrates and the trigger for such symmetry breaking in non-mammalian amniotes have remained unknown. Here we examined how L-R asymmetry is established in two reptiles, Madagascar ground gecko and Chinese softshell turtle. Both of these reptiles appear to lack motile cilia at the LRO. The expression of the Nodal gene at the LRO in the reptilian embryos was found to be asymmetric, in contrast to that in vertebrates such as mouse that are dependent on cilia for L-R patterning. Two paralogues of the Nodal gene derived from an ancient gene duplication are retained and expressed differentially in cilia-dependent and cilia-independent vertebrates. The expression of these two Nodal paralogues is similarly controlled in the lateral plate mesoderm but regulated differently at the LRO. Our in-depth analysis of reptilian embryos thus suggests that mammals and non-mammalian amniotes deploy distinct strategies dependent on different Nodal paralogues for rendering Nodal activity asymmetric at the LRO.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.