ReviewEuropean journal of clinical nutrition2020
Vitamin D testing: advantages and limits of the current assays.
Review in European journal of clinical nutrition, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 71 papers, 6 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
71 citing papers in PubMed, 6 syntheses or guidelines pooled it, 127 citations in OpenAlex.
- Investigating the Inflammatory Link Between Vitamin D and Hidradenitis Suppurativa: A Systematic Review and Causal Inference Analysis.International journal of molecular sciences · 2026Pooled it
- Vitamin D Deficiency in Kazakhstani Children: Insights from a Systematic Review and Meta-Analysis.Medicina (Kaunas, Lithuania) · 2025Pooled it
- Effect of vitamin D status and vitamin D supplementation on immune function and prevention of acute respiratory tract infections in dark-skinned individuals: a systematic review and meta-analysis.Public health nutrition · 2024Pooled it
- Association between vitamin D level and respiratory distress syndrome: A systematic review and meta-analysis.PloS one · 2023Pooled it
- Associations of Prenatal Vitamin D status with Oral Health in Offspring: A Systematic Review.Oral health & preventive dentistry · 2022Pooled it
- Vitamin D insufficiency is high in Malaysia: A systematic review and meta-analysis of studies on vitamin D status in Malaysia.Frontiers in nutrition · 2022Pooled it
- Calcifediol is superior to cholecalciferol in improving vitamin D status in postmenopausal women: a randomized trial.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2021Trial
- Article
- Comparison of LC-MS/MS and CLIA Methods for Vitamin D Measurement in an Unselected Outpatient Cohort: Statistical Evaluation and Impact on Clinical Classification.Diagnostics (Basel, Switzerland) · 2026Article
- Vitamin D and Uterine Fibroids: Insights into Pathophysiology and Therapeutic Potential.Endocrine reviews · 2026Review
- Interlaboratory comparison with a reference measurement procedure (RMP) for determining 24,25-dihydroxyvitamin DAnalytical and bioanalytical chemistry · 2026Article
- Vitamin D Deficiency and Replacement Challenges in Type 1 Gastric Neuroendocrine Tumors: A Comparative Study.Nutrients · 2026Article
- Effect of freezing and cryostorage on follicular fluid vitamin D levels.Reproduction & fertility · 2026Article
- Decoding Vitamin D Intake: How Much Is Too Much?Advances in experimental medicine and biology · 2026Review
- Combating Bacterial Infections with Vitamin D-Induced Antimicrobial Peptides.Advances in experimental medicine and biology · 2026Review
- Vitamin D and Mineral Ion Regulation.Advances in experimental medicine and biology · 2026Review
- Evaluation of the Performance of New Fluorescence Immunoassay POCTs for Determining the Value of Vitamin D in Whole Blood.Molecules (Basel, Switzerland) · 2025Article
- Exploring Vitamin D Trends Through Big Data Analysis.Nutrients · 2025Article
- A label-free impedimetric immunosensor based on nitrogen-doped graphene acid for sensitive detection of vitamin DMikrochimica acta · 2025Article
- Comparative Analysis of a Rapid Quantitative Immunoassay to the Reference Methodology for the Measurement of Blood Vitamin D Levels.Methods and protocols · 2025Article
11 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
14 authors at 12 institutions in 11 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Vitamin D deficiency and insufficiency has become a pandemic health problem with a consequent increase of requests for determining circulating levels of 25-hydroxyvitamin D [25(OH)D]. However, the analytical performance of these immunoassays, including radioimmunoassay and ELISA, is highly variable, and even mass spectrometric methods, which nowadays serves as the gold standard for the quantitatively determination of 25(OH)D, do not necessarily produce comparable results, creating limitations for the definition of normal vitamin D status ranges. To solve this problem, great efforts have been made to promote standardization of laboratory assays, which is important to achieve comparable results across different methods and manufacturers. In this review, we performed a systematic analysis evaluating critically the advantages and limits of the current assays available for the measure of vitamin D status, i.e., circulating 25(OH)D and its metabolites, making suggestions that could be used in the clinical practice. Moreover, we also suggest the use of alternatives to blood test, including standardized surveys that may be of value in alerting health-care professionals about the vitamin D status of their patients.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.