Evidence map›Paper›PMID 31907339›Full record

ArticleAging2020

Concomitant memantine and

Qiu-Jun Wang, Yue-E Shen, Xin Wang, Shuang Fu, Xin Zhang, Yi-Na Zhang, Rui-Tao Wang

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Aging, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 67 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
67citing papers in PubMed, 3 pooled it
6.9field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

67 citing papers in PubMed, 3 syntheses or guidelines pooled it, 138 citations in OpenAlex.

  1. Pooled it
  2. The microbiota-gut- hippocampus axis.Frontiers in neuroscience · 2022
    Pooled it
  3. Pooled it
  4. Review
  5. Review
  6. Review
  7. Review
  8. Review
  9. Review
  10. Review
  11. Article
  12. Review
  13. Review
  14. Article
  15. Review
  16. Review
  17. Review
  18. Review
  19. Review
  20. Article

7 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 1 country.

Qiu-Jun WangGeneral Practice Department, The Second Affiliated Hospital, Harbin Medical University, Harbin 150086, China.
Yue-E ShenDepartment of Neurology, The First Affiliated Hospital of Harbin Medical University, Harbin 150001, China.
Xin WangDepartment of Internal Medicine, Harbin Medical University Cancer Hospital, Harbin Medical University, Harbin 150081, China.
Shuang FuDepartment of Internal Medicine, Harbin Medical University Cancer Hospital, Harbin Medical University, Harbin 150081, China.
Xin ZhangDepartment of Internal Medicine, Harbin Medical University Cancer Hospital, Harbin Medical University, Harbin 150081, China.
Yi-Na ZhangDepartment of Geriatrics, The Second Affiliated Hospital, Harbin Medical University, Harbin 150086, China.
Rui-Tao WangDepartment of Internal Medicine, Harbin Medical University Cancer Hospital, Harbin Medical University, Harbin 150081, China.
Harbin Medical University · CNSecond Affiliated Hospital of Harbin Medical University · CNFirst Affiliated Hospital of Harbin Medical University · CNThird Affiliated Hospital of Harbin Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Trimethylamine-N-oxide (TMAO) is a gut microbial metabolite that promotes Alzheimer's disease (AD) progression. Given that probiotics can alleviate AD symptoms by inhibiting the synthesis of TMAO, here we investigated the correlation between TMAO and cognitive deterioration by measuring TMAO levels in the plasma of choline-treated APP/PS1 mice (an AD mouse model) with and without probiotic treatments. We found that declines in

Indexed as

Lactiplantibacillus plantarumAlzheimer DiseaseAnimalsAnimals, Genetically ModifiedBiomarkersCholineCognitive DysfunctionDietary SupplementsDisease Models, AnimalGastrointestinal MicrobiomeMaleMemantineMetagenomicsMiceProbioticsPyramidal CellsBiomarkersCholineMemantineAlzheimer’s diseaseAPP/PS1 micecognitive behaviorL. plantarumtrimethylamine-N-oxide

Identifiers

PMID31907339
PMCPMC6977692
OpenAlexW2999504562

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.