Evidence map›Paper›PMID 31907281›Full record

ArticleThe Journal of biological chemistry2020

Cross-linking modifications of HDL apoproteins by oxidized phospholipids: structural characterization,

Detao Gao, Mohammad Z Ashraf, Lifang Zhang, Niladri Kar, Tatiana V Byzova, Eugene A Podrez

Open access · hybridAbstract read
In one paragraph

Article in The Journal of biological chemistry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.7field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 17 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Detao GaoDepartment of Inflammation and Immunity, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio 44195.
Mohammad Z AshrafDepartment of Inflammation and Immunity, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio 44195.
Lifang ZhangDepartment of Inflammation and Immunity, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio 44195.
Niladri KarDepartment of Inflammation and Immunity, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio 44195.
Tatiana V ByzovaDepartment of Neurosciences, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio 44195.
Eugene A PodrezDepartment of Inflammation and Immunity, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio 44195. Electronic address: podreze@ccf.org.
Cleveland Clinic Lerner College of Medicine · US

Funding

Structure Basis for Talin-mediated Integrin ActivationP01HL073311 · NHLBI · CLEVELAND CLINIC LERNER COM-CWRU · PI BYZOVA, TATIANA V · 2004 to 2019
$27.4M
Pathophysiological Activities of Oxidized PhospholipidsR01HL077213 · NHLBI · CLEVELAND CLINIC LERNER COM-CWRU · PI PODREZ, EUGENE A · 2005 to 2018
$4.5M
Platelets in CancerR01HL142772 · NHLBI · CLEVELAND CLINIC LERNER COM-CWRU · PI BYZOVA, TATIANA V · 2018 to 2021
$2.6M
Role of TLR2 in angiogenesisR01HL145536 · NHLBI · CLEVELAND CLINIC LERNER COM-CWRU · PI BYZOVA, TATIANA V · 2019 to 2022
$2.6M
Mechanism of atheroprotective function of Akt3 kinaseR01HL126738 · NHLBI · CLEVELAND CLINIC LERNER COM-CWRU · PI PODREZ, EUGENE A · 2015 to 2018
$1.6M
High-End Instrumentation (HEI) Grant Program (S10)S10OD023436 · OD · CLEVELAND CLINIC LERNER COM-CWRU · PI WILLARD, BELINDA BELLE · 2017 to 2017
$873k
NHLBI NIH HHS P01 HL073311NHLBI NIH HHS R01 HL077213NHLBI NIH HHS R01 HL126738NHLBI NIH HHS R01 HL142772NHLBI NIH HHS R01 HL145536NIH HHS S10 OD023436
6 · The paper itself

Abstract

Apolipoprotein A-I (apoA-I) is cross-linked and dysfunctional in human atheroma. Although multiple mechanisms of apoA-I cross-linking have been demonstrated

Indexed as

AnimalsAortaApolipoprotein A-IChromatography, LiquidHumansHydrogen PeroxideLipoproteins, HDLLipoproteins, HDL3MacrophagesMiceNitric OxideOxidation-ReductionOxidative PhosphorylationPhospholipidsReceptors, LDLTandem Mass SpectrometryApolipoprotein A-IHydrogen PeroxideLDLR protein, humanLipoproteins, HDLLipoproteins, HDL3Nitric OxidePhospholipidsReceptors, LDLapolipoproteinatherosclerosiscardiovascular diseasecholesterol effluxcross-linkinghigh-density lipoprotein (HDL)lipid metabolismoxidative stressoxidized phospholipid-apoprotein adductoxidized phospholipidsphospholipid metabolism

Identifiers

PMID31907281
PMCPMC7029106
OpenAlexW2999804564

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.