Evidence map›Paper›PMID 31907268›Full record

ReviewJournal of immunology (Baltimore, Md. : 1950)2020

Neuronal Regulation of Cutaneous Immunity.

Jonathan A Cohen, Jianing Wu, Daniel H Kaplan

Open access · bronzeAbstract readReview
In one paragraph

Review in Journal of immunology (Baltimore, Md. : 1950), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
3.7field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 31 citations in OpenAlex.

  1. Article
  2. Article
  3. TRPV1Mucosal immunology · 2022
    Article
  4. Article
  5. Article
  6. Review
  7. Review
  8. Review
  9. Review
  10. The Global Emergency of Novel Coronavirus (SARS-CoV-2): An Update of the Current Status and Forecasting.International journal of environmental research and public health · 2020
    Review
  11. Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 2 countries.

Jonathan A CohenDepartments of Dermatology and Immunology, University of Pittsburgh, Pittsburgh, PA 15261.
Jianing WuDepartments of Dermatology and Immunology, University of Pittsburgh, Pittsburgh, PA 15261.ORCID 0000-0003-1296-1290
Daniel H KaplanDepartments of Dermatology and Immunology, University of Pittsburgh, Pittsburgh, PA 15261; dankaplan@Pitt.edu.ORCID 0000-0003-0598-0047
University of Pittsburgh · US

Funding

Immune Functions of Cutaneous NociceptorsR01AR071720 · NIAMS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Daniel H Kaplan · 2017 to 2026
$4.1M
Nociceptors are Sufficient for Cutaneous InflammationF30AI147396 · NIAID · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI COHEN, JONATHAN · 2019 to 2021
$101k
NIAID NIH HHS F30 AI147396NIAMS NIH HHS R01 AR071720
6 · The paper itself

Abstract

The skin is innervated by numerous sensory afferent neurons that respond to a diverse array of stimuli ranging from gentle touch to noxious pain. Various features of the immune system-pathogen recognition, secretion of soluble mediators-are shared with the nervous system. This has led to the recognition that neurons share some functions with innate immune cells and have the capacity to recognize pathogens and participate in innate immune responses. Neuroimmune interactions are bidirectional. Soluble mediators from immune cells activate neurons and soluble mediators from neurons can activate immune cells. In this review, we will focus on the interplay between neurons and innate immunity in the skin in the context of host defense and inflammation.

Indexed as

AnimalsHumansImmunity, InnateNeuroimmunomodulationSensory Receptor CellsSkin

Identifiers

PMID31907268
PMCPMC7583491
OpenAlexW3000628215

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.