Evidence map›Paper›PMID 31907220›Full record

ArticleMolecular cancer therapeutics2020

Targeting Tumor Neoangiogenesis via Targeted Adenoviral Vector to Achieve Effective Cancer Gene Therapy for Disseminated Neoplastic Disease.

Myungeun Lee, Zhi Hong Lu, Jie Li, Elena A Kashentseva, Igor P Dmitriev, Samir A Mendonca, David T Curiel

Open access · bronzeAbstract read
In one paragraph

Article in Molecular cancer therapeutics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.1field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 7 citations in OpenAlex.

  1. Oncolytic Virotherapy in Solid Tumors: A Current Review.BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy · 2025
    Review
  2. Review
  3. Review
  4. Review
  5. Advanced genetic engineering to achieve in vivo targeting of adenovirus utilizing camelid single domain antibody.Journal of controlled release : official journal of the Controlled Release Society · 2021
    Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Myungeun LeeDivision of Cancer Biology, Department of Radiation Oncology, School of Medicine, Washington University in St. Louis, St. Louis, Missouri.
Zhi Hong LuDivision of Cancer Biology, Department of Radiation Oncology, School of Medicine, Washington University in St. Louis, St. Louis, Missouri.
Jie LiDivision of Cancer Biology, Department of Radiation Oncology, School of Medicine, Washington University in St. Louis, St. Louis, Missouri.
Elena A KashentsevaDivision of Cancer Biology, Department of Radiation Oncology, School of Medicine, Washington University in St. Louis, St. Louis, Missouri.
Igor P DmitrievDivision of Cancer Biology, Department of Radiation Oncology, School of Medicine, Washington University in St. Louis, St. Louis, Missouri.
Samir A MendoncaDivision of Cancer Biology, Department of Radiation Oncology, School of Medicine, Washington University in St. Louis, St. Louis, Missouri.
David T CurielDivision of Cancer Biology, Department of Radiation Oncology, School of Medicine, Washington University in St. Louis, St. Louis, Missouri. dcuriel@wustl.edu.
Washington University in St. Louis · US

Funding

Novel targeted adenovirusR01CA211096 · NCI · WASHINGTON UNIVERSITY · PI CURIEL, DAVID TERRY · 2017 to 2021
$1.7M
NCI NIH HHS R01 CA211096
6 · The paper itself

Abstract

The application of cancer gene therapy has heretofore been restricted to local, or locoregional, neoplastic disease contexts. This is owing to the lack of gene transfer vectors, which embody the requisite target cell selectivity

Indexed as

Genetic TherapyAdenoviridaeAnimalsApoptosisBiomarkers, TumorCapsid ProteinsCell ProliferationGene Expression Regulation, NeoplasticGenetic VectorsHumansKidney NeoplasmsMiceMice, Inbred NODMice, SCIDNeovascularization, PathologicPromoter Regions, GeneticBiomarkers, TumorCapsid ProteinsReceptors, Cell SurfaceROBO4 protein, humanRoundabout Proteins

Identifiers

PMID31907220
PMCPMC7155772
OpenAlexW2999193811

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.