Evidence map›Paper›PMID 31907188›Full record

ArticleAntimicrobial agents and chemotherapy2020

Derivatives of the Antimalarial Drug Mefloquine Are Broad-Spectrum Antifungal Molecules with Activity against Drug-Resistant Clinical Isolates.

Marhiah C Montoya, Sarah Beattie, Kathryn M Alden, Damian J Krysan

Abstract read
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed.

  1. Article
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  4. Article
  5. Review
  6. Screening and transcriptomic analysis of anti-Frontiers in microbiology · 2025
    Article
  7. Article
  8. Article
  9. Article
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  12. Review
  13. Baicalin promotes β-1,3-glucan exposure inFrontiers in cellular and infection microbiology · 2024
    Article
  14. Article
  15. Review
  16. Review
  17. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Marhiah C MontoyaClinical and Translational Science Institute, University of Rochester School of Medicine and Dentistry, Rochester, New York, USA.
Sarah BeattieDepartment of Pediatrics, University of Iowa Carver College of Medicine, Iowa City, Iowa, USA.
Kathryn M AldenDepartment of Pediatrics, University of Iowa Carver College of Medicine, Iowa City, Iowa, USA.
Damian J KrysanDepartment of Pediatrics, University of Iowa Carver College of Medicine, Iowa City, Iowa, USA damian-krysan@uiowa.edu.

Funding

The University of Rochester's Clinical and Translational Science InstituteUL1TR002001 · NCATS · UNIVERSITY OF ROCHESTER · PI WILSON, KAREN M., ZAND, MARTIN S · 2016 to 2024
$34.6M
NRSA Training CoreTL1TR002000 · NCATS · UNIVERSITY OF ROCHESTER · PI THAKAR, JUILEE, VAN WIJNGAARDEN, EDWIN · 2016 to 2024
$4.1M
Characterization of Activity and Mechanism of Novel Fungicidal Anti-Cryptococcal MoleculesR21AI125094 · NIAID · UNIVERSITY OF ROCHESTER · PI KRYSAN, DAMIAN J · 2016 to 2017
$421k
Development of a high throughput-compatible assay for screening filamentous fungiF32AI145160 · NIAID · UNIVERSITY OF IOWA · PI BEATTIE, SARAH R. · 2020 to 2022
$185k
NCATS NIH HHS TL1 TR002000NCATS NIH HHS UL1 TR002001NIAID NIH HHS F32 AI145160NIAID NIH HHS R21 AI125094
6 · The paper itself

Abstract

The antifungal pharmacopeia is critically small, particularly in light of the recent emergence of multidrug-resistant pathogens, such as

Indexed as

A549 CellsAntifungal AgentsAntimalarialsCandidaCandida albicansCryptococcus neoformansDrug Resistance, FungalFluconazoleHep G2 CellsHumansMefloquineMicrobial Sensitivity TestsAntifungal AgentsAntimalarialsFluconazoleMefloquineantifungalantifungal agentsAspergillusCandidaCandida aurisCryptococcusCryptococcus neoformansmefloquinerepurposing

Identifiers

PMID31907188
PMCPMC7038245

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.