ArticleCritical care (London, England)2020
High Quality Targeted Temperature Management (TTM) After Cardiac Arrest.
Article in Critical care (London, England), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
49 citing papers in PubMed, 1 synthesis or guideline pooled it, 113 citations in OpenAlex.
- Targeted temperature management following out-of-hospital cardiac arrest: a systematic review and network meta-analysis of temperature targets.Intensive care medicine · 2021Pooled it
- Impact of rewarming rate on interleukin-6 levels in patients with shockable cardiac arrest receiving targeted temperature management at 33 °C: the ISOCRATE pilot randomized controlled trial.Critical care (London, England) · 2021Trial
- Timing of hypothermic temperature control does not affect neurological outcomes after cardiac arrest: a systematic review and meta-analysis.Intensive care medicine experimental · 2026Review
- In-hospital resuscitation treatments and neurological outcomes after out-of-hospital cardiac arrest during national academic meeting days: a nationwide retrospective study in Japan.Resuscitation plus · 2026Article
- A Machine Learning Model to Predict Treatment Effect Associated with Targeted Temperature Management After Cardiac Arrest.Neurocritical care · 2026Article
- Serum lactate to albumin ratio at hospital arrival and neurological outcome of out-of-hospital cardiac arrest: a nationwide multicenter observational study.Clinical and experimental emergency medicine · 2025Article
- High-Quality Targeted Temperature Management After Cardiac Arrest; Results from the Korean Hypothermia Network Prospective Registry.Journal of clinical medicine · 2025Article
- Current Perspectives on Rehabilitation Following Return of Spontaneous Circulation After Sudden Cardiac Arrest: A Narrative Review.Healthcare (Basel, Switzerland) · 2025Review
- Current practice in pediatric post-cardiac arrest care: a national survey among Italian pediatric intensivists.Resuscitation plus · 2025Article
- The "SOOTEST-ICU" bundle for optimizing cerebral hypoxia and reperfusion to minimize brain injury after resuscitation from cardiac arrest.World journal of emergency medicine · 2025Article
- Personalized Predictions of Therapeutic Hypothermia Outcomes in Cardiac Arrest Patients with Shockable Rhythms Using Explainable Machine Learning.Diagnostics (Basel, Switzerland) · 2025Article
- Temperature Control after Cardiac Arrest: A Narrative Review from a Developing Country Perspective.Arquivos brasileiros de cardiologia · 2025Review
- Agreement of in-ear temperature to core body temperature measures during invasive whole-body cooling for hypothermic circulatory arrest in aortic arch surgery.Scientific reports · 2024Observational
- Variability in temperature control practices amongst the Influence of Cooling duration on Efficacy in Cardiac Arrest Patients (ICECAP) trial.Resuscitation · 2024Article
- Targeted temperature control following traumatic brain injury: ESICM/NACCS best practice consensus recommendations.Critical care (London, England) · 2024Article
- Hypothermia vs Normothermia in Patients With Cardiac Arrest and Nonshockable Rhythm: A Meta-Analysis.JAMA neurology · 2024Article
- A review on targeted temperature management for cardiac arrest and traumatic brain injury.Frontiers in neuroscience · 2024Review
- Remarkable recovery following prolonged out-of-hospital cardiac arrest: hypoxic-ischemic encephalopathy (HIE) versus posterior reversible encephalopathy syndrome (PRES)-a case report.AME case reports · 2024Article
- High-quality targeted temperature management combined with decompressive craniectomy in patients with poor-grade aneurysmal subarachnoid hemorrhage: a secondary analysis of a multicenter prospective study.Frontiers in neurology · 2024Article
- Factors influencing deviation from target temperature during targeted temperature management in postcardiac arrest patients.Open heart · 2023Observational
Corrections and comments
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Authors and funding
3 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Targeted temperature management (TTM) is a complex intervention used with the aim of minimizing post-anoxic injury and improving neurological outcome after cardiac arrest. There is large variability in the devices used to achieve cooling and in protocols (e.g., for induction, target temperature, maintenance, rewarming, sedation, management of post-TTM fever). This variability can explain the limited benefits of TTM that have sometimes been reported. We therefore propose the concept of "high-quality TTM" as a way to increase the effectiveness of TTM and standardize its use in future interventional studies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.