ArticleBMC cancer2020
Effect of adjuvant chemotherapy on survival benefit in stage III colon cancer patients stratified by age: a Japanese real-world cohort study.
Article in BMC cancer, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
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15 citing papers in PubMed, 1 synthesis or guideline pooled it, 43 citations in OpenAlex.
- Patterns of age disparities in colon and lung cancer survival: a systematic narrative literature review.BMJ open · 2021Pooled it
- Recurrence-free survival in patients with stage III colorectal cancer who did or did not complete adjuvant chemotherapy.Surgery today · 2026Article
- Added value of adjuvant chemotherapy in patients with node-positive pT1-2 colon cancer: a national SNAPSHOT analysis.The oncologist · 2026Article
- Survival Analysis of 4 Different Age Groups of Pancreatic Ductal Adenocarcinoma After Radical Resection From Retrospective Multi-Center Analysis (YPB-003).Cancer medicine · 2025Article
- A machine learning-based model for predicting survival in patients with Rectosigmoid Cancer.PloS one · 2025Article
- Real-life experiences and barriers to adjuvant chemotherapy in Saudi patients with advanced stage II and stage III colon cancer.Saudi journal of gastroenterology : official journal of the Saudi Gastroenterology Association · 2024Article
- Real-world analysis of survival benefit of surgery and adjuvant therapy in elderly patients with colorectal cancer.Scientific reports · 2023Article
- An age-group analysis on the efficacy of chemotherapy in older adult patients with metastatic biliary tract cancer: a Japanese cancer registry cohort study.BMC gastroenterology · 2023Article
- Validation of algorithms to identify colorectal cancer patients from administrative claims data of a Japanese hospital.BMC health services research · 2023Article
- Article
- Effects of deficient mismatch repair on the prognosis of patients with stage II and stage III colon cancer during different postoperative periods.BMC cancer · 2022Article
- Risk of cardiovascular disease among different fluoropyrimidine-based chemotherapy regimens as adjuvant treatment for resected colorectal cancer.Frontiers in cardiovascular medicine · 2022Article
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- Multicentre cohort study of the impact of percutaneous coronary intervention on patients with concurrent cancer and ischaemic heart disease.BMC cardiovascular disorders · 2021Article
- Geriatric assessment domains to predict overall survival in older cancer patients: An analysis of functional status, comorbidities, and nutritional status as prognostic factors.Cancer medicine · 2020Article
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundAdjuvant chemotherapy is relatively underused in older patients with colon cancer in Japan, and its age-specific effects on clinical outcomes remain unclear. This study aimed to assess the effect of adjuvant chemotherapy on survival benefit in stage III colon cancer patients stratified by age in a Japanese real-world setting.
methodsIn this multi-center retrospective cohort study, we analyzed patient-level information through a record linkage of population-based cancer registry data and administrative claims data. The study population comprised patients aged ≥18 years who received a pathological diagnosis of stage III colon cancer and underwent curative resection between 2010 and 2014 at 36 cancer care hospitals in Osaka Prefecture, Japan. Patients were divided into two groups based on age at diagnosis (< 75 and ≥ 75 years). The effect of adjuvant chemotherapy was analyzed using Cox proportional hazards regression models for all-cause mortality with inverse probability weighting of propensity scores. Adjusted hazard ratios were estimated for both age groups.
resultsA total of 783 patients were analyzed; 476 (60.8%) were aged < 75 years and 307 (39.2%) were aged ≥75 years. The proportion of older patients who received adjuvant chemotherapy (36.8%) was substantially lower than that of younger patients (73.3%). In addition, the effect of adjuvant chemotherapy was different between the age groups: the adjusted hazard ratio was 0.56 (95% confidence interval: 0.33-0.94, P = 0.027) in younger patients and 1.07 (0.66-1.74, P = 0.78) in older patients.
conclusionsThe clinical effectiveness of adjuvant chemotherapy in older patients with stage III colon cancer appears limited under current utilization practices.
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