Evidence map›Paper›PMID 31906951›Full record

ArticleJournal of biomedical science2020

Melatonin restores Muc2 depletion induced by V. vulnificus VvpM via melatonin receptor 2 coupling with Gαq.

Young-Min Lee, Jong Pil Park, Young Hyun Jung, Hyun Jik Lee, Jun Sung Kim, Gee Euhn Choi, Ho Jae Han, Sei-Jung Lee

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of biomedical science, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
2.3field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 13 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Young-Min LeeDepartment of Pharmaceutical Engineering, Daegu Haany University, Hanuidae-ro 1, BioCenter, Suite 709, Gyeongsan-si, Gyeongsangbuk-do, 38610, South Korea.
Jong Pil ParkDepartment of Pharmaceutical Engineering, Daegu Haany University, Hanuidae-ro 1, BioCenter, Suite 709, Gyeongsan-si, Gyeongsangbuk-do, 38610, South Korea.
Young Hyun JungDepartment of Veterinary Physiology, College of Veterinary Medicine, Research Institute for Veterinary Science, and BK21 PLUS Program for Creative Veterinary Research Center, Seoul National University, Seoul, 08826, South Korea.
Hyun Jik LeeDepartment of Veterinary Physiology, College of Veterinary Medicine, Research Institute for Veterinary Science, and BK21 PLUS Program for Creative Veterinary Research Center, Seoul National University, Seoul, 08826, South Korea.
Jun Sung KimDepartment of Veterinary Physiology, College of Veterinary Medicine, Research Institute for Veterinary Science, and BK21 PLUS Program for Creative Veterinary Research Center, Seoul National University, Seoul, 08826, South Korea.
Gee Euhn ChoiDepartment of Veterinary Physiology, College of Veterinary Medicine, Research Institute for Veterinary Science, and BK21 PLUS Program for Creative Veterinary Research Center, Seoul National University, Seoul, 08826, South Korea.
Ho Jae HanDepartment of Veterinary Physiology, College of Veterinary Medicine, Research Institute for Veterinary Science, and BK21 PLUS Program for Creative Veterinary Research Center, Seoul National University, Seoul, 08826, South Korea.
Sei-Jung LeeDepartment of Pharmaceutical Engineering, Daegu Haany University, Hanuidae-ro 1, BioCenter, Suite 709, Gyeongsan-si, Gyeongsangbuk-do, 38610, South Korea. sjlee@dhu.ac.kr.ORCID http://orcid.org/0000-0002-3115-952X
Seoul National University · KRDaegu Haany University · KR

Funding

National Research Foundation of Korea NRF- 2016R1D1A1B03930458
6 · The paper itself

Abstract

backgroundMelatonin (5-methoxy-N-acetyltryptamine), a hormone produced in the pineal gland, has a variety of biological functions as an antioxidant, but a functional role of melatonin in the regulation of intestinal mucin (Muc) production during bacterial infection has yet to be described in detail. In this study, we investigate the effects of melatonin during Muc2 repression elicited by the Gram-negative bacterium V. vulnificus.

methodsMucus-secreting human HT29-MTX cells were used to study the functional role of melatonin during Muc2 depletion induced by the recombinant protein (r) VvpM produced by V. vulnificus. The regulatory effects of melatonin coupling with melatonin receptor 2 (MT

resultsRecombinant protein (r) VvpM significantly reduced the level of Muc2 in HT29-MTX cells. The repression of Muc2 induced by rVvpM was significantly restored upon a treatment with melatonin (1 μM), which had been inhibited by the knockdown of MT

conclusionsThese results demonstrate that melatonin acting on MT

Indexed as

DNA MethylationAnimalsBacterial ToxinsGTP-Binding Protein alpha Subunits, Gq-G11HT29 CellsHumansMelatoninMiceMucin-2Receptor, Melatonin, MT2Vibrio InfectionsVibrio vulnificusBacterial ToxinsGNAQ protein, humanGTP-Binding Protein alpha Subunits, Gq-G11MelatoninMUC2 protein, humanMucin-2Receptor, Melatonin, MT2MelatoninMelatonin receptor 2MucinReactive oxygen speciesrVvpMV. vulnificus

Identifiers

PMID31906951
PMCPMC6943958
OpenAlexW3005026184

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.