Evidence map›Paper›PMID 31906909›Full record

ArticleBMC public health2020

C-reactive protein mediates the association between leisure-time physical activity and lung function in middle-aged and older adults.

Meng Chen, Chuanying Huang, Wenjing Feng, Yujie Li, Yili Wu

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC public health, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.0field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
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  4. Mediating effect of behavioural intention on podcast acceptance.Education and information technologies · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Meng ChenDepartment of Epidemiology and Health Statistics, Public Health College, Qingdao University, No. 38 Deng Zhou Street, Qingdao, 266021, Shandong, China.
Chuanying HuangDepartment of Epidemiology and Health Statistics, Public Health College, Qingdao University, No. 38 Deng Zhou Street, Qingdao, 266021, Shandong, China.
Wenjing FengDepartment of Geriatrics, Affiliated Hospital of Qingdao University, No. 59 Haier Road, Qingdao, 266100, Shandong, China.
Yujie LiDepartment of Epidemiology and Health Statistics, Public Health College, Qingdao University, No. 38 Deng Zhou Street, Qingdao, 266021, Shandong, China.
Yili WuDepartment of Epidemiology and Health Statistics, Public Health College, Qingdao University, No. 38 Deng Zhou Street, Qingdao, 266021, Shandong, China. yiliwu79@163.com.ORCID http://orcid.org/0000-0002-5289-2552
Qingdao University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAlthough previous studies have reported the benefits of physical activity (PA) to lung function in middle-aged and older adults, the biological mechanisms are still unclear. This study aimed to assess the extent to which C-reactive protein (CRP) mediates the association between leisure-time PA and lung function.

methodsA population-based sample was recruited from English Longitudinal Study of Ageing (ELSA), Wave 6 (2012-2013). PA was self-reported by questionnaires. CRP was analyzed from peripheral blood. Lung function parameters including forced expiratory volume in 1 s (FEV1) and forced vital capacity (FVC) were measured by using a spirometer. Baron and Kenny's causal steps method and multiple linear regression models based on the Karlson/Holm/Bree (KHB) method were used to assess the mediating effect.

resultsAmong 6875 participants, 28.4% were classified into low PA, 49.8% into moderate PA, and 21.8% into high PA. Multiple linear regression models suggested that higher PA was associated with lower levels of CRP (β = - 0.048, P = 0.002 for moderate PA; β = - 0.108, P < 0.001 for high PA). CRP negatively correlated with FEV1 (β = - 0.180, P < 0.001) and FVC (β = - 0.181, P < 0.001). Higher levels of PA were associated with better FEV1 (β = 0.085, P < 0.001 for moderate PA; β = 0.150, P < 0.001 for high PA) and FVC (β = 0.131, P < 0.001 for moderate PA; β = 0.211, P < 0.001 for high PA). After introducing the CRP into the models, regression coefficients of PA with FEV1 (β = 0.077, P < 0.001 for moderated PA; β = 0.130, P < 0.001 for high PA) and FVC (β = 0.123, P < 0.001 for moderated PA; β = 0.188, P < 0.001 for high PA) decreased. The indirect effect of high PA on lung function via CRP was significant, with 9.42-12.99% of the total effect being mediated.

conclusionsThe association between PA and lung function is mediated by CRP, suggesting that this association may be partially explained by an inflammation-related biological mechanism. This finding highlights the possible importance of PA in systemic inflammation and lung function, thus, middle-aged and older adults should be encouraged to enhance PA levels.

Indexed as

Leisure ActivitiesAgedC-Reactive ProteinExerciseFemaleForced Expiratory VolumeHumansLongitudinal StudiesMaleMiddle AgedRespiratory Function TestsSelf ReportVital CapacityC-Reactive ProteinC-reactive proteinLeisure-time physical activityLung functionMediating effect

Identifiers

PMID31906909
PMCPMC6945486
OpenAlexW2997448803

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.