ArticleBMC public health2020
Early-life exposure to the Chinese famine of 1959-61 and risk of Hyperuricemia: results from the China health and retirement longitudinal study.
Article in BMC public health, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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16 citing papers in PubMed, 1 synthesis or guideline pooled it, 23 citations in OpenAlex.
- Association between early exposure to famine and risk of renal impairment in adulthood: a systematic review and meta-analysis.Nutrition & diabetes · 2024Pooled it
- Early-life nutritional deprivation and multimorbidity in middle- aged and older adults: a longitudinal exploratory mediation analysis of biological aging.Frontiers in nutrition · 2026Article
- Association between famine exposure during early life and the risk of hyperuricemia in adulthood: a systematic review and meta-analysis.BMC nutrition · 2025Article
- The association between childhood hunger experiences and health in middle and old age: a longitudinal study over 10 years.BMC public health · 2025Article
- Association between fetal exposure to the Chinese famine and cognitive decline in adulthood: a retrospective cohort study.Frontiers in nutrition · 2025Article
- Article
- Exposure to Chinese famine and the risk of hyperuricemia in later life: a population-based cross-sectional study.Frontiers in nutrition · 2024Article
- Early-life undernutrition in the great Chinese famine and the risk of early natural menopause: a retrospective cohort study in Western China.Frontiers in nutrition · 2024Article
- Correlation of Great Chinese Famine Exposure During Early Life to Prevalence of Kidney Stone in Adulthood.International journal of general medicine · 2023Article
- Article
- Early life exposure to famine and risk of dyslipidemia in adults: a systematic review and Meta-analysis.Journal of diabetes and metabolic disorders · 2022Review
- Trend dynamics of gout prevalence among the Chinese population, 1990-2019: A joinpoint and age-period-cohort analysis.Frontiers in public health · 2022Article
- Sex Differences at Early Old Stage in Glycolipid Metabolism and Fatty Liver in Offspring Prenatally Exposed to Chinese Great Famine.Frontiers in nutrition · 2022Article
- Association of early-life undernutrition and risk of dyslipidemia in adulthood: a population-based cohort study.BMC public health · 2021Article
- Individual and combined association analysis of famine exposure and serum uric acid with hypertension in the mid-aged and older adult: a population-based cross-sectional study.BMC cardiovascular disorders · 2021Article
- Fetal Exposure to Chinese Famine Increases Obesity Risk in Adulthood.International journal of environmental research and public health · 2020Article
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2 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundShort-term starvation has been related to hyperuricemia. However, little is known about the long-term effect of early-life exposure to famine on hyperuricemia risk in adulthood.
methodsThe analysis included 2383 participants from the China Health and Retirement Longitudinal Study in 2015. Hyperuricemia was diagnosed as serum uric acid ≥7 mg/dL in men and serum uric acid ≥6 mg/dL in women. Famine exposure subgroups were defined as unexposed (born between October 1, 1962, and September 30, 1964), fetal-exposed (born between October 1, 1959, and September 30, 1961), and early-childhood exposed (born between October 1, 1956, and September 1, 1958). The association between early-life famine exposure and hyperuricemia risk was assessed using multivariate logistic regression.
resultsThe prevalence of hyperuricemia in the unexposed, fetal-exposed, and early-childhood exposed participants was 10.7, 14.1, 11.1%, respectively. Compared with unexposed and early-childhood exposed participants combined as an age-balanced control, fetal-exposed participants showed an increased risk of hyperuricemia in adulthood (OR = 1.41; 95% CI: 1.06-1.88), after adjusting for gender, marital status, famine severity, residence, smoking, drinking, BMI, hypertension, and diabetes. The famine effect on hyperuricemia was accentuated by overweight or obesity (P for interaction = 0.042). Compared with unexposed and BMI < 24 kg/m
conclusionFamine exposure in the fetal stage was associated with an increased risk of hyperuricemia in adulthood.
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