ArticleBMC medical genetics2020
Alpha and beta-Thalassemia mutations in Hubei area of China.
Article in BMC medical genetics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 28 citations in OpenAlex.
- Family trios/quartets analysis based on the Newborn Genomic Atlas for Thalassemia project in Guangxi.BMC medicine · 2025Article
- A direct multiplex isothermal amplification-reverse dot blot hybridization system for β-thalassemia diagnosis.Annals of hematology · 2025Article
- Impact of transferrin levels on iron accumulation in transfusion-dependent beta-thalassemia: A genotype-specific analysis.Journal of medical biochemistry · 2025Article
- Identification of a novel 10.7 kb deletion (Nanning deletion; -ζMolecular biology reports · 2025Article
- Genetic analysis of thalassemia in putian: comparative insights into mutation spectra with other global regions.Annals of hematology · 2025Article
- Analysis of thalassemia genotypes and HbA2 test results in pregnant women in Shenzhen, China.Scientific reports · 2025Article
- Gene Editing of the Endogenous Cryptic 3' Splice Site Corrects the RNA Splicing Defect in the βHuman gene therapy · 2024Article
- Molecular Characterization of α- and β-Thalassemia Among Children Less Than 18 Years Old in Guizhou, China.Journal of clinical laboratory analysis · 2024Article
- Could the 3'UTR+101G>C Mutation Detected in Two Sibling Cases Be a Mutation Affecting the Clinical Presentation in Thalassemia Patients?Mediterranean journal of hematology and infectious diseases · 2024Article
- A particular focus on the prevalence of α-thalassemia and β-thalassemia among pregnant women in Changsha County, Hunan Province.Frontiers in genetics · 2024Article
- Differences in medical costs between TCM users and TCM nonusers in inpatients with thalassemia.BMC health services research · 2023Article
- Prevalence and molecular characterization of alpha and beta-Thalassemia mutations among Hakka people in southern China.Genetics and molecular biology · 2022Article
- Molecular Spectrum, Ethnic and Geographical Distribution of Thalassemia in the Southern Area of Hainan, China.Frontiers in pediatrics · 2022Article
- Prevalence and molecular spectrum of α- and β-globin gene mutations in Hainan, China.International journal of hematology · 2021Article
- Gene Mutation Spectrum of Thalassemia Among Children in Yunnan Province.Frontiers in pediatrics · 2020Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThalassemia is a group of inherited hemoglobic disorders resulting from defects in the synthesis of one or more of the hemoglobin chains, which is one of the most prevalent inherited disorders in southern China. Only few studies reported the molecular characterization of α- and β-Thalassemia in Hubei Province in the central of China.
methodsA total of 4889 clinically suspected cases of thalassemia were analyzed by Gap-PCR, PCR-based reverse dot blot (RDB).
results1706 (33.8%) subjects harbored thalassemia mutations, including 539 (11.0%) subjects with α-thalassemia, 1140 (23.3%) subjects with β-thalassemia mutations, and 25 (0.51%) subjects with both α- and β-thalassemia mutations. Seven genotypes of α-thalassemia mutations and 29 genotypes of β-thalassemia mutations were characterized. --
conclusionsOur data indicated great heterogeneity and extensive spectrum of thalassemias in Hubei province of China.
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