Evidence map›Paper›PMID 31906869›Full record

ArticleBMC genomics2020

Overexpression of a modified eIF4E regulates potato virus Y resistance at the transcriptional level in potato.

Pablo A Gutierrez Sanchez, Lavanya Babujee, Helena Jaramillo Mesa, Erica Arcibal, Megan Gannon, Dennis Halterman, Molly Jahn, Jiming Jiang, Aurélie M Rakotondrafara

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC genomics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
4.4field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 29 citations in OpenAlex.

  1. Article
  2. Review
  3. CRISPR-Cas Gene Editing Technology in Potato.International journal of molecular sciences · 2025
    Review
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  6. Review
  7. Review
  8. Article
  9. Article
  10. Insight into aphid mediatedFrontiers in microbiology · 2022
    Review
  11. CRISPR-Cas9 Targeting of theFrontiers in microbiology · 2022
    Article
  12. Article
  13. Article
  14. Review
  15. Article
  16. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 2 countries.

Pablo A Gutierrez SanchezLaboratorio de Microbiología Industrial, Facultad de Ciencias, Universidad Nacional de Colombia Sede Medellín, Calle 59 A N 63-20, Medellín, Colombia.
Lavanya BabujeeDepartment of Plant Pathology, University of Wisconsin-Madison, 1630 Linden Drive, Madison, WI, 53706, USA.
Helena Jaramillo MesaDepartment of Plant Pathology, University of Wisconsin-Madison, 1630 Linden Drive, Madison, WI, 53706, USA.
Erica ArcibalDepartment of Plant Pathology, University of Wisconsin-Madison, 1630 Linden Drive, Madison, WI, 53706, USA.
Megan GannonDepartment of Plant Pathology, University of Wisconsin-Madison, 1630 Linden Drive, Madison, WI, 53706, USA.
Dennis HaltermanU.S. Department of Agriculture-Agricultural Research Service, Madison, WI, 53726, USA.
Molly JahnDepartment of Agronomy, University of Wisconsin-Madison, Moore Hall, 1575 Linden Drive, Madison, WI, 53706, USA.
Jiming JiangDepartment of Plant Biology, Department of Horticulture, Michigan State University, East Lansing, MI, 48824, USA.
Aurélie M RakotondrafaraDepartment of Plant Pathology, University of Wisconsin-Madison, 1630 Linden Drive, Madison, WI, 53706, USA. rakotondrafa@wisc.edu.ORCID http://orcid.org/0000-0002-1859-3743
University of Wisconsin–Madison · USMichigan State University · USUnited States Department of Agriculture · USUniversidad Nacional de Colombia · CO

Funding

Hatch Formula Act MSN 179998USDA Agricultural Research Service (US) 58-5090-5-056
6 · The paper itself

Abstract

backgroundPotato virus Y (PVY) is a major pathogen of potatoes with major impact on global agricultural production. Resistance to PVY can be achieved by engineering potatoes to express a recessive, resistant allele of eukaryotic translation initiation factor eIF4E, a host dependency factor essential to PVY replication. Here we analyzed transcriptome changes in eIF4E over-expressing potatoes to shed light on the mechanism underpinning eIF4E-mediated recessive PVY resistance.

resultsAs anticipated, modified eIF4E-expressing potatoes demonstrated a high level of resistance, eIF4E expression, and an unexpected suppression of the susceptible allele transcript, likely explaining the bulk of the potent antiviral phenotype. In resistant plants, we also detected marked upregulation of genes involved in cell stress responses.

conclusionsOur results reveal a previously unanticipated second layer of signaling attributable to eIF4E regulatory control, and potentially relevant to establishment of a broader, more systematic antiviral host defense.

Indexed as

Gene Expression Regulation, PlantAllelesCapsicumDisease ResistanceEukaryotic Initiation Factor-4EGene Expression ProfilingGene OntologyGenes, RecessivePlant DiseasesPlant ProteinsPlants, Genetically ModifiedPotyvirusSignal TransductionSolanum tuberosumEukaryotic Initiation Factor-4EPlant ProteinseIF4EFeedback regulationOxidative stressPotato virus YPotyvirusesRecessive resistance

Identifiers

PMID31906869
PMCPMC6945410
OpenAlexW2999554592

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.