Evidence map›Paper›PMID 31906709›Full record

ArticleThe American journal of psychiatry2020

Efficacy of Deep Brain Stimulation of the Ventral Anterior Limb of the Internal Capsule for Refractory Obsessive-Compulsive Disorder: A Clinical Cohort of 70 Patients.

Damiaan Denys, Ilse Graat, Roel Mocking, Pelle de Koning, Nienke Vulink, Martijn Figee, Pieter Ooms, Mariska Mantione, Pepijn van den Munckhof, Rick Schuurman

2 registry-linked trialsAbstract read
PubMed Publisher
In one paragraph

Article in The American journal of psychiatry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 83 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
83citing papers in PubMed, 5 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04958096 narecruitingnot on this mapstarted 2021, after this paper: background citation

Adjunct Cortical Stimulation With Deep Brain Stimulation (DBS) to Treat Obsessive Compulsive Disorder (OCD)

TypeinterventionalSponsorAndrew Moses Lee, MD, PhDRan2021 to 2026Enrolled15ConditionsObsessive-Compulsive DisorderArmsStandard Therapeutic Deep Brain Stimulation, Cortical Stimulation for PFC, Cortical Stimulation for ACC
NCT06347978 naactive not recruitingnot on this mapstarted 2024, after this paper: background citation

A Double-Blinded, Randomized, Crossover Trial of Stereoencephalography- Guided Four-Lead Personalized Deep Brain Stimulation for Treatment-Refractory Obsessive Compulsive Disorder (SEEG-Guided DBS for OCD)

TypeinterventionalSponsorAndrew Moses Lee, MD, PhDRan2024 to 2028Enrolled10ConditionsObsessive-Compulsive Disorder, OCDArmsDeep Brain Stimulation
3 · Its place in the literature

Who cites it

83 citing papers in PubMed, 5 syntheses or guidelines pooled it.

  1. Pooled it
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  4. Invasive and Non-invasive Neurostimulation for OCD.Current topics in behavioral neurosciences · 2021
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  17. A Multi-Symptom Circuit Architecture of Obsessive-Compulsive Disorder.medRxiv : the preprint server for health sciences · 2025
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23 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors.

Damiaan DenysThe Department of Psychiatry, University of Amsterdam (Denys, Graat, Mocking, de Koning, Vulink, Ooms); the Department of Psychiatry, Mount Sinai Hospital, New York (Figee); the Department of Neurosurgery, University of Amsterdam (van den Munckhof, Schuurman); and the Department of Neurology and Neurosurgery, University of Amsterdam Utrecht, Utrecht, the Netherlands (Mantione).
Ilse GraatThe Department of Psychiatry, University of Amsterdam (Denys, Graat, Mocking, de Koning, Vulink, Ooms); the Department of Psychiatry, Mount Sinai Hospital, New York (Figee); the Department of Neurosurgery, University of Amsterdam (van den Munckhof, Schuurman); and the Department of Neurology and Neurosurgery, University of Amsterdam Utrecht, Utrecht, the Netherlands (Mantione).
Roel MockingThe Department of Psychiatry, University of Amsterdam (Denys, Graat, Mocking, de Koning, Vulink, Ooms); the Department of Psychiatry, Mount Sinai Hospital, New York (Figee); the Department of Neurosurgery, University of Amsterdam (van den Munckhof, Schuurman); and the Department of Neurology and Neurosurgery, University of Amsterdam Utrecht, Utrecht, the Netherlands (Mantione).
Pelle de KoningThe Department of Psychiatry, University of Amsterdam (Denys, Graat, Mocking, de Koning, Vulink, Ooms); the Department of Psychiatry, Mount Sinai Hospital, New York (Figee); the Department of Neurosurgery, University of Amsterdam (van den Munckhof, Schuurman); and the Department of Neurology and Neurosurgery, University of Amsterdam Utrecht, Utrecht, the Netherlands (Mantione).
Nienke VulinkThe Department of Psychiatry, University of Amsterdam (Denys, Graat, Mocking, de Koning, Vulink, Ooms); the Department of Psychiatry, Mount Sinai Hospital, New York (Figee); the Department of Neurosurgery, University of Amsterdam (van den Munckhof, Schuurman); and the Department of Neurology and Neurosurgery, University of Amsterdam Utrecht, Utrecht, the Netherlands (Mantione).
Martijn FigeeThe Department of Psychiatry, University of Amsterdam (Denys, Graat, Mocking, de Koning, Vulink, Ooms); the Department of Psychiatry, Mount Sinai Hospital, New York (Figee); the Department of Neurosurgery, University of Amsterdam (van den Munckhof, Schuurman); and the Department of Neurology and Neurosurgery, University of Amsterdam Utrecht, Utrecht, the Netherlands (Mantione).
Pieter OomsThe Department of Psychiatry, University of Amsterdam (Denys, Graat, Mocking, de Koning, Vulink, Ooms); the Department of Psychiatry, Mount Sinai Hospital, New York (Figee); the Department of Neurosurgery, University of Amsterdam (van den Munckhof, Schuurman); and the Department of Neurology and Neurosurgery, University of Amsterdam Utrecht, Utrecht, the Netherlands (Mantione).
Mariska MantioneThe Department of Psychiatry, University of Amsterdam (Denys, Graat, Mocking, de Koning, Vulink, Ooms); the Department of Psychiatry, Mount Sinai Hospital, New York (Figee); the Department of Neurosurgery, University of Amsterdam (van den Munckhof, Schuurman); and the Department of Neurology and Neurosurgery, University of Amsterdam Utrecht, Utrecht, the Netherlands (Mantione).
Pepijn van den MunckhofThe Department of Psychiatry, University of Amsterdam (Denys, Graat, Mocking, de Koning, Vulink, Ooms); the Department of Psychiatry, Mount Sinai Hospital, New York (Figee); the Department of Neurosurgery, University of Amsterdam (van den Munckhof, Schuurman); and the Department of Neurology and Neurosurgery, University of Amsterdam Utrecht, Utrecht, the Netherlands (Mantione).
Rick SchuurmanThe Department of Psychiatry, University of Amsterdam (Denys, Graat, Mocking, de Koning, Vulink, Ooms); the Department of Psychiatry, Mount Sinai Hospital, New York (Figee); the Department of Neurosurgery, University of Amsterdam (van den Munckhof, Schuurman); and the Department of Neurology and Neurosurgery, University of Amsterdam Utrecht, Utrecht, the Netherlands (Mantione).

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveDeep brain stimulation (DBS) is an effective treatment option for patients with refractory obsessive-compulsive disorder (OCD). However, clinical experience with DBS for OCD remains limited. The authors examined the tolerability and effectiveness of DBS in an open study of patients with refractory OCD.

methodsSeventy consecutive patients, including 16 patients from a previous trial, received bilateral DBS of the ventral anterior limb of the internal capsule (vALIC) between April 2005 and October 2017 and were followed for 12 months. Primary effectiveness was assessed by the change in scores on the Yale-Brown Obsessive Compulsive Scale (Y-BOCS) from baseline until the 12-month follow-up. Response was defined by a ≥35% decrease in Y-BOCS score, partial response was defined by a 25%-34% decrease, and nonresponse was defined by a <25% decrease. Secondary effectiveness measures were the Hamilton Anxiety Rating Scale (HAM-A) and the Hamilton Depression Rating Scale (HAM-D).

resultsY-BOCS, HAM-A, and HAM-D scores all decreased significantly during the first 12 months of DBS. Twelve months of DBS resulted in a mean Y-BOCS score decrease of 13.5 points (SD=9.4) (40% reduction; effect size=1.5). HAM-A scores decreased by 13.4 points (SD=9.7) (55%; effect size=1.4), and HAM-D scores decreased by 11.2 points (SD=8.8) (54%; effect size=1.3). At the 12-month follow-up, 36 of the 70 patients were categorized as responders (52%), 12 patients as partial responders (17%), and 22 patients as nonresponders (31%). Adverse events included transient symptoms of hypomania, agitation, impulsivity, and sleeping disorders.

conclusionsThese results confirm the effectiveness and safety of DBS of the vALIC for patients with treatment-refractory OCD in a regular clinical setting.

Indexed as

Deep Brain StimulationAdultAnxietyFemaleHumansInternal CapsuleMaleMiddle AgedObsessive-Compulsive DisorderPsychiatric Status Rating ScalesTreatment OutcomeDeep Brain StimulationObsessive-Compulsive DisorderOutcome StudiesVentral Anterior Limb

Identifiers

PMID31906709

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.