Evidence map›Paper›PMID 31906585›Full record

ArticleJournal of clinical medicine2020

Differential Gene Expression in Circulating CD14

Anke Liepelt, Philipp Hohlstein, Hendrik Gussen, Jia Xue, Anna C Aschenbrenner, Thomas Ulas, Lukas Buendgens, Klaudia T Warzecha, Matthias Bartneck, Tom Luedde and 4 more

Open access · goldAbstract read
In one paragraph

Article in Journal of clinical medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
1.7field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 32 citations in OpenAlex.

  1. Article
  2. Article
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  6. Whole blood ratio ofFrontiers in medicine · 2024
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  9. Article
  10. Frontiers in immunology · 2023
    Article
  11. Review
  12. Article
  13. Article
  14. Article
  15. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 2 institutions in 2 countries.

Anke LiepeltDepartment of Medicine III, University Hospital Aachen, RWTH Aachen University, 52074 Aachen, Germany.
Philipp HohlsteinDepartment of Medicine III, University Hospital Aachen, RWTH Aachen University, 52074 Aachen, Germany.
Hendrik GussenDepartment of Medicine III, University Hospital Aachen, RWTH Aachen University, 52074 Aachen, Germany.
Jia XueGenomics and Immunoregulation, Life & Medical Sciences (LIMES) Institute, University of Bonn, 53115 Bonn, Germany.
Anna C AschenbrennerGenomics and Immunoregulation, Life & Medical Sciences (LIMES) Institute, University of Bonn, 53115 Bonn, Germany.
Thomas UlasGenomics and Immunoregulation, Life & Medical Sciences (LIMES) Institute, University of Bonn, 53115 Bonn, Germany.
Lukas BuendgensDepartment of Medicine III, University Hospital Aachen, RWTH Aachen University, 52074 Aachen, Germany.
Klaudia T WarzechaDepartment of Medicine III, University Hospital Aachen, RWTH Aachen University, 52074 Aachen, Germany.
Matthias BartneckDepartment of Medicine III, University Hospital Aachen, RWTH Aachen University, 52074 Aachen, Germany.
Tom LueddeDepartment of Medicine III, University Hospital Aachen, RWTH Aachen University, 52074 Aachen, Germany.
Christian TrautweinDepartment of Medicine III, University Hospital Aachen, RWTH Aachen University, 52074 Aachen, Germany.
Joachim L SchultzeGenomics and Immunoregulation, Life & Medical Sciences (LIMES) Institute, University of Bonn, 53115 Bonn, Germany.ORCID 0000-0003-2812-9853
Alexander KochDepartment of Medicine III, University Hospital Aachen, RWTH Aachen University, 52074 Aachen, Germany.
Frank TackeDepartment of Medicine III, University Hospital Aachen, RWTH Aachen University, 52074 Aachen, Germany.
Universitätsklinikum Aachen · DEUniversity of Bonn · DE

Funding

Deutsche Forschungsgemeinschaft Ta434/5-1, CRC1382 and SFB/TRR57Horizon 2020 No 733100: SYSCID, A systems medicine approach to chronic inflammatory diseases
6 · The paper itself

Abstract

Critical illness and sepsis are characterized by drastic changes in the systemic innate immune response, particularly involving monocytes. The exact monocyte activation profile during sepsis, however, has remained obscure. Therefore, we prospectively analyzed the gene expression profile of circulating CD14

Indexed as

biomarkerICUinnate immunitymonocytesmortalityprognosissepsis

Identifiers

PMID31906585
PMCPMC7019484
OpenAlexW2997961849

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.