Evidence map›Paper›PMID 31906485›Full record

ArticleInternational journal of molecular sciences2020

Systemic Oxidative Stress Is Increased in Postmenopausal Women and Independently Associates with Homocysteine Levels.

Arno R Bourgonje, Amaal Eman Abdulle, Areej M Al-Rawas, Muna Al-Maqbali, Mohsin Al-Saleh, Marvin B Enriquez, Sultan Al-Siyabi, Khamis Al-Hashmi, Intisar Al-Lawati, Marian L C Bulthuis and 4 more

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Trial
  3. Trial
  4. Article
  5. Review
  6. Article
  7. Sleep Disorders in Climacteric Women: Glutathione, Glutathione S-Transferase P1 and Gut Microbiome Interrelation.Pathophysiology : the official journal of the International Society for Pathophysiology · 2025
    Article
  8. Review
  9. Article
  10. Homocysteine and risk of interstitial lung disease: A mendelian randomization approach to causal inference.Sarcoidosis, vasculitis, and diffuse lung diseases : official journal of WASOG · 2025
    Article
  11. Article
  12. Article
  13. Chronic intermittent hypoxia-induced hypertension: the impact of sex hormones.American journal of physiology. Regulatory, integrative and comparative physiology · 2024
    Review
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Arno R BourgonjeDepartment of Gastroenterology and Hepatology, University Medical Center Groningen, University of Groningen, 9713 GZ Groningen, The Netherlands.ORCID 0000-0001-5754-3821
Amaal Eman AbdulleDivision of Vascular Medicine, Department of Internal Medicine, University Medical Center Groningen, University of Groningen, 9713 GZ Groningen, The Netherlands.ORCID 0000-0003-3766-2238
Areej M Al-RawasDepartment of Biochemistry, College of Medicine & Health Sciences, Sultan Qaboos University, P.O. Box 35, Al-Khoud 123, Muscat, Oman.
Muna Al-MaqbaliDepartment of Biochemistry, College of Medicine & Health Sciences, Sultan Qaboos University, P.O. Box 35, Al-Khoud 123, Muscat, Oman.
Mohsin Al-SalehDepartment of Biochemistry, College of Medicine & Health Sciences, Sultan Qaboos University, P.O. Box 35, Al-Khoud 123, Muscat, Oman.
Marvin B EnriquezDepartment of Microbiology and Immunology, College of Medicine & Health Sciences, Sultan Qaboos University, P.O. Box 35, Al-Khoud 123, Muscat, Oman.
Sultan Al-SiyabiDepartment of Physiology, College of Medicine & Health Sciences, Sultan Qaboos University, P.O. Box 35, Al-Khoud 123, Muscat, Oman.ORCID 0000-0003-3336-9093
Khamis Al-HashmiDepartment of Physiology, College of Medicine & Health Sciences, Sultan Qaboos University, P.O. Box 35, Al-Khoud 123, Muscat, Oman.
Intisar Al-LawatiDepartment of Physiology, College of Medicine & Health Sciences, Sultan Qaboos University, P.O. Box 35, Al-Khoud 123, Muscat, Oman.
Marian L C BulthuisDepartment of Pathology and Medical Biology, Section Pathology, University Medical Center Groningen, University of Groningen, 9713 GZ Groningen, The Netherlands.
Douwe J MulderDivision of Vascular Medicine, Department of Internal Medicine, University Medical Center Groningen, University of Groningen, 9713 GZ Groningen, The Netherlands.
Sanne J GordijnDepartment of Obstetrics & Gynecology, University Medical Center Groningen, University of Groningen, 9713 GZ Groningen, The Netherlands.
Harry van GoorDepartment of Pathology and Medical Biology, Section Pathology, University Medical Center Groningen, University of Groningen, 9713 GZ Groningen, The Netherlands.ORCID 0000-0002-6670-1577
Jumana SalehDepartment of Biochemistry, College of Medicine & Health Sciences, Sultan Qaboos University, P.O. Box 35, Al-Khoud 123, Muscat, Oman.

Funding

The Research Council (TRC) of Oman RC/MED/BIOC/15/01
6 · The paper itself

Abstract

Oxidative stress plays a pivotal role in the pathogenesis of cardiovascular diseases (CVD). Postmenopausal women have an increased risk of developing CVD due to decreased estrogen availability, which is accompanied by increased oxidative stress. Serum free thiols (R-SH) provide a robust and powerful read-out of systemic oxidative stress. In this study, we aimed to establish serum levels of free thiols and explore associations between free thiols and demographic, clinical, and biochemical parameters related to obesity and the risk for developing CVD in both pre- and postmenopausal women. Serum free thiols were measured in a cohort consisting of healthy pre- (

Indexed as

AdultCardiovascular DiseasesCohort StudiesCross-Sectional StudiesFemaleHomocysteineHumansMiddle AgedObesityOmanOxidative StressPostmenopausePremenopauseRisk FactorsSulfhydryl CompoundsHomocysteineSulfhydryl Compoundscardiovascular diseasefree thiolshomocysteinemenopauseobesityoxidative stresspostmenopausal womenrisk factors

Identifiers

PMID31906485
PMCPMC6982320

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.