Evidence map›Paper›PMID 31906353›Full record

ArticleToxins2020

Revisiting Old Ionophore Lasalocid as a Novel Inhibitor of Multiple Toxins.

Nassim Mahtal, Yu Wu, Jean-Christophe Cintrat, Julien Barbier, Emmanuel Lemichez, Daniel Gillet

Open access · goldAbstract read
In one paragraph

Article in Toxins, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.6field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 12 citations in OpenAlex.

  1. Animals : an open access journal from MDPI · 2025
    Article
  2. Research Progress in Mutagenesis Techniques forMini reviews in medicinal chemistry · 2025
    Review
  3. Article
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Nassim MahtalService d'Ingénierie Moléculaire des Protéines (SIMOPRO), CEA, Université Paris-Saclay, F-91191 Gif-sur-Yvette, France.
Yu WuService d'Ingénierie Moléculaire des Protéines (SIMOPRO), CEA, Université Paris-Saclay, F-91191 Gif-sur-Yvette, France.
Jean-Christophe CintratService de Chimie Bio-organique et Marquage (SCBM), CEA, Université Paris-Saclay, F-91191 Gif-sur-Yvette, France.ORCID 0000-0001-5758-8077
Julien BarbierService d'Ingénierie Moléculaire des Protéines (SIMOPRO), CEA, Université Paris-Saclay, F-91191 Gif-sur-Yvette, France.ORCID 0000-0003-2187-4973
Emmanuel LemichezUnité des Toxines Bactériennes, Institut Pasteur, ERL 6002, F-75015 Paris, France.
Daniel GilletService d'Ingénierie Moléculaire des Protéines (SIMOPRO), CEA, Université Paris-Saclay, F-91191 Gif-sur-Yvette, France.ORCID 0000-0003-0477-3599
Commissariat à l'Énergie Atomique et aux Énergies Alternatives · FRInstitut Pasteur · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The ionophore lasalocid is widely used as a veterinary drug against coccidiosis. We found recently that lasalocid protects cells from two unrelated bacterial toxins, the cytotoxic necrotizing factor-1 (CNF1) from

Indexed as

Bacterial ToxinsBiological TransportDiphtheria ToxinEndosomesEscherichia coliExotoxinsGolgi ApparatusHumansIonophoresLasalocidLysosomesProtective AgentsShiga Toxin 1Bacterial ToxinsDiphtheria ToxinExotoxinsIonophoresLasalocidProtective AgentsShiga Toxin 1Golgilasalocidtoxin

Identifiers

PMID31906353
PMCPMC7020423
OpenAlexW2996863343

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.