Evidence map›Paper›PMID 31906343›Full record

ArticleMaterials (Basel, Switzerland)2020

Exploratory Full-Field Strain Analysis of Regenerated Bone Tissue from Osteoinductive Biomaterials.

Marta Peña Fernández, Cameron Black, Jon Dawson, David Gibbs, Janos Kanczler, Richard O C Oreffo, Gianluca Tozzi

Open access · goldAbstract read
In one paragraph

Article in Materials (Basel, Switzerland), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.4field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 18 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Marta Peña FernándezSchool of Mechanical and Design Engineering, University of Portsmouth, Portsmouth PO1 3DJ, UK.ORCID 0000-0002-3534-8838
Cameron BlackBone & Joint Research Group, Centre for Human Development Stem Cells and Regeneration, Faculty of Medicine, University of Southampton, Southampton SO16 6YD, UK.
Jon DawsonBone & Joint Research Group, Centre for Human Development Stem Cells and Regeneration, Faculty of Medicine, University of Southampton, Southampton SO16 6YD, UK.
David GibbsBone & Joint Research Group, Centre for Human Development Stem Cells and Regeneration, Faculty of Medicine, University of Southampton, Southampton SO16 6YD, UK.
Janos KanczlerBone & Joint Research Group, Centre for Human Development Stem Cells and Regeneration, Faculty of Medicine, University of Southampton, Southampton SO16 6YD, UK.
Richard O C OreffoBone & Joint Research Group, Centre for Human Development Stem Cells and Regeneration, Faculty of Medicine, University of Southampton, Southampton SO16 6YD, UK.ORCID 0000-0001-5995-6726
Gianluca TozziSchool of Mechanical and Design Engineering, University of Portsmouth, Portsmouth PO1 3DJ, UK.
University of Southampton · GBUniversity of Portsmouth · GBSouthampton Solent University · GB

Funding

Biotechnology and Biological Sciences Research Council BB/G010579/1Biotechnology and Biological Sciences Research Council BB/G010579/1,Biotechnology and Biological Sciences Research Council BB/L00609X/1Biotechnology and Biological Sciences Research Council BBSRC LO21071Medical Research Council MR/R015651/1UK Regenerative Medicine Platform Hub Acellular Approaches for Therapeutic Delivery MR/K026682/1
6 · The paper itself

Abstract

Biomaterials for bone regeneration are constantly under development, and their application in critical-sized defects represents a promising alternative to bone grafting techniques. However, the ability of all these materials to produce bone mechanically comparable with the native tissue remains unclear. This study aims to explore the full-field strain evolution in newly formed bone tissue produced in vivo by different osteoinductive strategies, including delivery systems for BMP-2 release. In situ high-resolution X-ray micro-computed tomography (microCT) and digital volume correlation (DVC) were used to qualitatively assess the micromechanics of regenerated bone tissue. Local strain in the tissue was evaluated in relation to the different bone morphometry and mineralization for specimens (

Indexed as

biomaterialsbone regenerationdigital volume correlationin situ mechanicsmicroCT

Identifiers

PMID31906343
PMCPMC6981952
OpenAlexW2996819718

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.