Evidence map›Paper›PMID 31906326›Full record

ArticleInternational journal of environmental research and public health2020

Laboratory Parameters of Hemostasis, Adhesion Molecules, and Inflammation in Type 2 Diabetes Mellitus: Correlation with Glycemic Control.

Eleonora Palella, Rossella Cimino, Salvatore A Pullano, Antonino S Fiorillo, Elio Gulletta, Antonio Brunetti, Daniela P Foti, Marta Greco

Open access · goldAbstract read
In one paragraph

Article in International journal of environmental research and public health, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed, 2 pooled it
4.5field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 2 syntheses or guidelines pooled it, 46 citations in OpenAlex.

  1. Pooled it
  2. The Role of P-Selectin in COVID-19 Coagulopathy: An Updated Review.International journal of molecular sciences · 2021
    Pooled it
  3. Trial
  4. Article
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  6. Review
  7. Article
  8. Review
  9. Article
  10. Article
  11. Luteolin Alleviates Diabetic Nephropathy Fibrosis Involving AMPK/NLRP3/TGF-β Pathway.Diabetes, metabolic syndrome and obesity : targets and therapy · 2024
    Article
  12. Article
  13. Review
  14. Article
  15. Article
  16. Article
  17. Hyper-reactive platelets and type 2 diabetes.Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2022
    Article
  18. Review
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Eleonora PalellaDepartment of Health Sciences, University "Magna Græcia" of Catanzaro, Viale Europa, 88100 Catanzaro, Italy.
Rossella CiminoDepartment of Health Sciences, University "Magna Græcia" of Catanzaro, Viale Europa, 88100 Catanzaro, Italy.
Salvatore A PullanoDepartment of Health Sciences, University "Magna Græcia" of Catanzaro, Viale Europa, 88100 Catanzaro, Italy.ORCID 0000-0003-3391-1698
Antonino S FiorilloDepartment of Health Sciences, University "Magna Græcia" of Catanzaro, Viale Europa, 88100 Catanzaro, Italy.ORCID 0000-0001-6163-7804
Elio GullettaDepartment of Health Sciences, University "Magna Græcia" of Catanzaro, Viale Europa, 88100 Catanzaro, Italy.
Antonio BrunettiDepartment of Health Sciences, University "Magna Græcia" of Catanzaro, Viale Europa, 88100 Catanzaro, Italy.ORCID 0000-0003-1533-8779
Daniela P FotiDepartment of Health Sciences, University "Magna Græcia" of Catanzaro, Viale Europa, 88100 Catanzaro, Italy.ORCID 0000-0002-9536-5736
Marta GrecoDepartment of Health Sciences, University "Magna Græcia" of Catanzaro, Viale Europa, 88100 Catanzaro, Italy.ORCID 0000-0003-4192-3891
Magna Graecia University · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundType 2 diabetes mellitus (T2DM) is characterized by a prothrombotic state, predisposing to vascular complications. Some related markers, linking thrombophilia to hemostasis and inflammation, however, have been poorly explored in relation to patients' glycemia. We therefore investigated the association of laboratory hemostatic parameters, circulating adhesion molecules (ADMs), white blood cell (WBC) count, and neutrophil/lymphocyte ratio (NLR) with T2DM and glycemic control. RESEARCH

designIn this study, 82 subjects, grouped into T2DM patients (

resultsPT % activity, PAI-1, VCAM-1, WBC, and neutrophil counts were significantly higher in T2DM patients than in healthy subjects. Poor glycemic control (HbA1c ≥ 7%) was correlated with increased PT activity (

conclusionsBoth T2DM and poor glycemic control affect some parameters of hemostasis, inflammation, and adhesion molecules. Further studies are needed to establish their clinical utility as adjuvant markers for cardio-vascular risk in T2DM patients.

Indexed as

Cell Adhesion MoleculesDiabetes Mellitus, Type 2HemostasisInflammationAdultBiomarkersBlood GlucoseCardiovascular DiseasesCohort StudiesE-SelectinFemaleGlycated HemoglobinGlycemic IndexHumansIntercellular Adhesion Molecule-1MaleBiomarkersBlood GlucoseCell Adhesion MoleculesE-SelectinGlycated HemoglobinICAM1 protein, humanIntercellular Adhesion Molecule-1Plasminogen Activator Inhibitor 1P-SelectinSELE protein, humanSELP protein, humanSERPINE1 protein, humanVascular Cell Adhesion Molecule-1adhesion moleculeshemostasisinflammationprothrombotic risktype 2 diabetes mellitus

Identifiers

PMID31906326
PMCPMC6982208
OpenAlexW2997829020

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.