Evidence map›Paper›PMID 31906090›Full record

ArticleInternational journal of molecular sciences2019

Neuron-Like Cells Generated from Human Umbilical Cord Lining-Derived Mesenchymal Stem Cells as a New In Vitro Model for Neuronal Toxicity Screening: Using Magnetite Nanoparticles as an Example.

Uliana De Simone, Arsenio Spinillo, Francesca Caloni, Laura Gribaldo, Teresa Coccini

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.6field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 20 citations in OpenAlex.

  1. Article
  2. Article
  3. [Repair effect of different doses of human umbilical cord mesenchymal stem cells on white matter injury in neonatal rats].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2024
    Article
  4. Review
  5. Article
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 4 institutions in 1 country.

Uliana De SimoneLaboratory of Clinical & Experimental Toxicology, Toxicology Unit, ICS Maugeri SpA-Benefit Corporation, IRCCS Pavia, Via Maugeri 10, 27100 Pavia, Italy.
Arsenio SpinilloDepartment of Obstetrics and Gynecology, Fondazione IRCCS Policlinico San Matteo and University of Pavia, 27100 Pavia, Italy.
Francesca CaloniDipartimento di Medicina Veterinaria (DIMEVET), Università degli Studi di Milano, 20133 Milano, Italy.ORCID 0000-0003-2527-7754
Laura GribaldoChemical Safety and Alternative Methods Unit, Directorate F-Health, Consumers and Reference Materials, Directorate General Joint Research Centre, European Commission, 21027 Ispra, Italy.
Teresa CocciniLaboratory of Clinical & Experimental Toxicology, Toxicology Unit, ICS Maugeri SpA-Benefit Corporation, IRCCS Pavia, Via Maugeri 10, 27100 Pavia, Italy.
Istituti Clinici Scientifici Maugeri · ITJoint Research Centre · ITUniversity of Milan · ITUniversity of Pavia · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The wide employment of iron nanoparticles in environmental and occupational settings underlines their potential to enter the brain. Human cell-based systems are recommended as relevant models to reduce uncertainty and to improve prediction of human toxicity. This study aimed at demonstrating the in vitro differentiation of the human umbilical cord lining-derived-mesenchymal stem cells (hCL-MSCs) into neuron-like cells (hNLCs) and the benefit of using them as an ideal primary cell source of human origin for the neuronal toxicity of Fe

Indexed as

Gene Expression RegulationMaterials TestingHumansMagnetite NanoparticlesMesenchymal Stem CellsNerve Tissue ProteinsNeuronsUmbilical CordMagnetite NanoparticlesNerve Tissue Proteinsalternative methodscell-based assayenvironmental toxicologyFe3O4 nanoparticleshuman primary cell culturepredictive nanotoxicologysafety assessmenttoxicity-testing strategies

Identifiers

PMID31906090
PMCPMC6982086
OpenAlexW2998110751

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.