Evidence map›Paper›PMID 31906086›Full record

ArticleInternational journal of molecular sciences2019

Regional Differences in Tight Junction Protein Expression in the Blood-DRG Barrier and Their Alterations after Nerve Traumatic Injury in Rats.

Thomas J Lux, Xiawei Hu, Adel Ben-Kraiem, Robert Blum, Jeremy Tsung-Chieh Chen, Heike L Rittner

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.6field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 20 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Thomas J LuxDepartment of Anaesthesiology, University Hospital of Wuerzburg, 97074 Wuerzburg, Germany.ORCID 0000-0003-1049-9872
Xiawei HuDepartment of Anaesthesiology, University Hospital of Wuerzburg, 97074 Wuerzburg, Germany.
Adel Ben-KraiemDepartment of Anaesthesiology, University Hospital of Wuerzburg, 97074 Wuerzburg, Germany.
Robert BlumInstitute of Clinical Neurobiology, University Hospital of Wuerzburg, 94074 Wuerzburg, Germany.
Jeremy Tsung-Chieh ChenDepartment of Anaesthesiology, University Hospital of Wuerzburg, 97074 Wuerzburg, Germany.ORCID 0000-0002-8195-6770
Heike L RittnerDepartment of Anaesthesiology, University Hospital of Wuerzburg, 97074 Wuerzburg, Germany.ORCID 0000-0003-4867-0188
Universitätsklinikum Würzburg · DE

Funding

Deutsche Forschungsgemeinschaft Ri-817/13-1 and 817/15-1Graduate School of Life Sciences, University of Wuerzburg -Interdisziplinäres Zentrum für Klinische Forschung, Universitätsklinikum Würzburg ND-368Studienstiftung des Deutschen Volkes -
6 · The paper itself

Abstract

The nervous system is shielded by special barriers. Nerve injury results in blood-nerve barrier breakdown with downregulation of certain tight junction proteins accompanying the painful neuropathic phenotype. The dorsal root ganglion (DRG) consists of a neuron-rich region (NRR, somata of somatosensory and nociceptive neurons) and a fibre-rich region (FRR), and their putative epi-/perineurium (EPN). Here, we analysed blood-DRG barrier (BDB) properties in these physiologically distinct regions in Wistar rats after chronic constriction injury (CCI).

Indexed as

Gene Expression RegulationAnimalsGanglia, SpinalMaleNociceptorsPainPeripheral Nervous System DiseasesRatsRats, WistarTight Junction ProteinsTight Junction Proteinsclaudin-5dorsal root ganglionnerve injuryneuropathic paintight junction

Identifiers

PMID31906086
PMCPMC6981987
OpenAlexW2997350643

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.