Evidence map›Paper›PMID 31906015›Full record

ArticleInternational journal of molecular sciences2019

PHLDA1 Does Not Contribute Directly to Heat Shock-Induced Apoptosis of Spermatocytes.

Patryk Janus, Katarzyna Mrowiec, Natalia Vydra, Piotr Widłak, Agnieszka Toma-Jonik, Joanna Korfanty, Ryszard Smolarczyk, Wiesława Widłak

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 46% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 5 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Patryk JanusMaria Sklodowska-Curie Institute-Oncology Center, Gliwice Branch, Wybrzeże Armii Krajowej 15, 44-101 Gliwice, Poland.
Katarzyna MrowiecMaria Sklodowska-Curie Institute-Oncology Center, Gliwice Branch, Wybrzeże Armii Krajowej 15, 44-101 Gliwice, Poland.
Natalia VydraMaria Sklodowska-Curie Institute-Oncology Center, Gliwice Branch, Wybrzeże Armii Krajowej 15, 44-101 Gliwice, Poland.
Piotr WidłakMaria Sklodowska-Curie Institute-Oncology Center, Gliwice Branch, Wybrzeże Armii Krajowej 15, 44-101 Gliwice, Poland.ORCID 0000-0001-5099-4726
Agnieszka Toma-JonikMaria Sklodowska-Curie Institute-Oncology Center, Gliwice Branch, Wybrzeże Armii Krajowej 15, 44-101 Gliwice, Poland.
Joanna KorfantyMaria Sklodowska-Curie Institute-Oncology Center, Gliwice Branch, Wybrzeże Armii Krajowej 15, 44-101 Gliwice, Poland.
Ryszard SmolarczykMaria Sklodowska-Curie Institute-Oncology Center, Gliwice Branch, Wybrzeże Armii Krajowej 15, 44-101 Gliwice, Poland.
Wiesława WidłakMaria Sklodowska-Curie Institute-Oncology Center, Gliwice Branch, Wybrzeże Armii Krajowej 15, 44-101 Gliwice, Poland.ORCID 0000-0002-8440-9414
The Maria Sklodowska-Curie National Research Institute of Oncology · PL

Funding

National Science Centre, Poland 2014/13/B/NZ3/04650
6 · The paper itself

Abstract

Spermatocytes are among the most heat-sensitive cells and the exposure of testes to heat shock results in their Heat Shock Factor 1 (HSF1)-mediated apoptosis. Several lines of evidence suggest that pleckstrin-homology-like domain family A, member 1 (PHLDA1) plays a role in promoting heat shock-induced cell death in spermatogenic cells, yet its precise physiological role is not well understood. Aiming to elucidate the hypothetical role of PHLDA1 in HSF1-mediated apoptosis of spermatogenic cells we characterized its expression in mouse testes during normal development and after heat shock. We stated that transcription of

Indexed as

AnimalsAnimals, Genetically ModifiedApoptosisCloning, MolecularHeat-Shock ResponseHeat Shock Transcription FactorsMaleMiceNIH 3T3 CellsProto-Oncogene Proteins c-bcl-2SpermatocytesTestisTranscription FactorsHeat Shock Transcription FactorsHsf1 protein, mousePhlda1 protein, mousePmaip1 protein, mouseProto-Oncogene Proteins c-bcl-2Transcription Factorsapoptosisdetachmentheat shockHSF1PHLDA1spermatogenesis

Identifiers

PMID31906015
PMCPMC6982182
OpenAlexW2997016232

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.