Evidence map›Paper›PMID 31906008›Full record

ReviewInternational journal of molecular sciences2019

Inflammation and Oxidative Stress in Chronic Kidney Disease-Potential Therapeutic Role of Minerals, Vitamins and Plant-Derived Metabolites.

Shara Francesca Rapa, Biagio Raffaele Di Iorio, Pietro Campiglia, August Heidland, Stefania Marzocco

Registry-linked trialAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in International journal of molecular sciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05037604 (Factors Associated With Dermatoporosis), which is not on this map. Cited by 284 papers, 8 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
284citing papers in PubMed, 8 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05037604 completednot on this map

Factors Associated With Dermatoporosis

TypeobservationalSponsorUniversidad Autonoma de San Luis PotosíRan2018 to 2019Enrolled315ConditionsSenile PurpuraArmsQuestionnaire about associated factors, Self questionnaire diagnostic tool, Physical Examination
3 · Its place in the literature

Who cites it

284 citing papers in PubMed, 8 syntheses or guidelines pooled it.

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  9. Efficacy and Safety Analysis of Roxarestat in Regulating Renal Anemia in Patients on Maintenance Hemodialysis.Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy · 2026
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224 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Shara Francesca RapaDepartment of Pharmacy, School of Pharmacy, University of Salerno, Via Giovanni Paolo II 132, I-84084 Fisciano, SA, Italy.
Biagio Raffaele Di IorioUOC Nephrology AORN "San Giuseppe Moscati", C.da Amoretta, 83100 Avellino, Italy.ORCID 0000-0003-2779-4181
Pietro CampigliaDepartment of Pharmacy, School of Pharmacy, University of Salerno, Via Giovanni Paolo II 132, I-84084 Fisciano, SA, Italy.ORCID 0000-0002-1069-2181
August HeidlandDepartment of Internal Medicine and KfH Kidney Center, University of Würzburg, KfH Kidney Center Würzburg, 97080 Würzburg, Germany.
Stefania MarzoccoDepartment of Pharmacy, School of Pharmacy, University of Salerno, Via Giovanni Paolo II 132, I-84084 Fisciano, SA, Italy.ORCID 0000-0003-2333-1630

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Chronic kidney disease (CKD) is a debilitating pathology with various causal factors, culminating in end stage renal disease (ESRD) requiring dialysis or kidney transplantation. The progression of CKD is closely associated with systemic inflammation and oxidative stress, which are responsible for the manifestation of numerous complications such as malnutrition, atherosclerosis, coronary artery calcification, heart failure, anemia and mineral and bone disorders, as well as enhanced cardiovascular mortality. In addition to conventional therapy with anti-inflammatory and antioxidative agents, growing evidence has indicated that certain minerals, vitamins and plant-derived metabolites exhibit beneficial effects in these disturbances. In the current work, we review the anti-inflammatory and antioxidant properties of various agents which could be of potential benefit in CKD/ESRD. However, the related studies were limited due to small sample sizes and short-term follow-up in many trials. Therefore, studies of several anti-inflammatory and antioxidant agents with long-term follow-ups are necessary.

Indexed as

AnimalsAntioxidantsCytokinesDisease ProgressionHumansInflammationKidney Failure, ChronicKidney TransplantationMineralsOxidative StressPlant ExtractsRenal Insufficiency, ChronicVitaminsAntioxidantsCytokinesMineralsPlant ExtractsVitaminschronic kidney disease (CKD)inflammationmineralsoxidative stressplant-derived metabolitesuremic toxinsvitamins

Identifiers

PMID31906008
PMCPMC6981831

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.