Evidence map›Paper›PMID 31905906›Full record

ArticleInternational journal of molecular sciences2019

β-Galactosylceramidase Deficiency Causes Bone Marrow Vascular Defects in an Animal Model of Krabbe Disease.

Mirella Belleri, Daniela Coltrini, Marco Righi, Cosetta Ravelli, Sara Taranto, Paola Chiodelli, Stefania Mitola, Marco Presta, Arianna Giacomini

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.5field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Mirella BelleriDepartment of Molecular and Translational Medicine, University of Brescia, 25123 Brescia, Italy.
Daniela ColtriniDepartment of Molecular and Translational Medicine, University of Brescia, 25123 Brescia, Italy.
Marco RighiInstitute of Neuroscience, National Research Council, 20129 Milan, Italy.
Cosetta RavelliDepartment of Molecular and Translational Medicine, University of Brescia, 25123 Brescia, Italy.
Sara TarantoDepartment of Molecular and Translational Medicine, University of Brescia, 25123 Brescia, Italy.
Paola ChiodelliDepartment of Molecular and Translational Medicine, University of Brescia, 25123 Brescia, Italy.
Stefania MitolaDepartment of Molecular and Translational Medicine, University of Brescia, 25123 Brescia, Italy.
Marco PrestaDepartment of Molecular and Translational Medicine, University of Brescia, 25123 Brescia, Italy.ORCID 0000-0002-4398-8376
Arianna GiacominiDepartment of Molecular and Translational Medicine, University of Brescia, 25123 Brescia, Italy.
University of Brescia · ITNational Research Council · IT

Funding

Associazione Italiana per la Ricerca sul Cancro AIRC IG grant n° 18943Fondazione Cariplo grant n° 2016-0570
6 · The paper itself

Abstract

Krabbe disease (KD) is an autosomal recessive sphingolipidosis caused by the deficiency of the lysosomal hydrolase β-galactosylceramidase (GALC). Oligodendroglia degeneration and demyelination of the nervous system lead to neurological dysfunctions which are usually lethal by two years of age. At present, the only clinical treatment with any proven efficacy is hematopoietic stem-cell transplantation, which is more effective when administered in the neonatal period to presymptomatic recipients. Bone marrow (BM) sinusoidal endothelial cells (SECs) play a pivotal role in stem cell engraftment and reconstitution of hematopoiesis. Previous observations had shown significant alterations of microvascular endothelial cells in the brain of KD patients and in

Indexed as

AnimalsBone MarrowBrainCytokinesDisease Models, AnimalEndothelial CellsGalactosylceramidaseHematopoiesisHematopoietic Stem Cell TransplantationLeukodystrophy, Globoid CellMiceMice, Inbred C57BLPlatelet Endothelial Cell Adhesion Molecule-1Vascular Endothelial Growth Factor Receptor-2CytokinesGalactosylceramidaseKdr protein, mousePecam1 protein, mousePlatelet Endothelial Cell Adhesion Molecule-1Vascular Endothelial Growth Factor Receptor-2beta-galactosylceramidasebone marrowendotheliumKrabbe diseasetwitcher mice

Identifiers

PMID31905906
PMCPMC6982065
OpenAlexW2997305054

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.