Evidence map›Paper›PMID 31905878›Full record

ArticleMolecules (Basel, Switzerland)2019

Identifying Ortholog Selective Fragment Molecules for Bacterial Glutaredoxins by NMR and Affinity Enhancement by Modification with an Acrylamide Warhead.

Ram B Khattri, Daniel L Morris, Stephanie M Bilinovich, Erendra Manandhar, Kahlilah R Napper, Jacob W Sweet, David A Modarelli, Thomas C Leeper

Open access · goldAbstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecules (Basel, Switzerland), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.3field-weighted citation impact, top 49% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
  2. Article
  3. Using Structure-guided Fragment-Based Drug Discovery to TargetFrontiers in molecular biosciences · 2022
    Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 1 country.

Ram B KhattriDepartment of Physiology and Functional genomics, University of Florida, Gainesville, FL 32610, USA.ORCID 0000-0001-9991-263X
Daniel L MorrisDepartment of Chemistry and Biochemistry, The University of Akron, Akron, OH 44325, USA.
Stephanie M BilinovichDepartment of Pediatrics and Human Development, Michigan State University, East Lansing, MI 48824, USA.
Erendra ManandharDepartment of Chemistry, Berea College, Berea, KY 40404, USA.
Kahlilah R NapperDepartment of Chemistry and Biochemistry, The University of Akron, Akron, OH 44325, USA.
Jacob W SweetDepartment of Chemistry and Biochemistry, The University of Akron, Akron, OH 44325, USA.
David A ModarelliDepartment of Chemistry and Biochemistry, The University of Akron, Akron, OH 44325, USA.ORCID 0000-0002-7441-8130
Thomas C LeeperDepartment of Chemistry and Biochemistry, Kennesaw State University, GA 30144, USA.
University of Akron · USBerea College · USKennesaw State University · USMichigan State University · USUniversity of Florida · US

Funding

NIH HHS R01 5R01GM116889-02NIH HHS R15 7R15GM110678-03NIH HHS R15 GM116110-01
6 · The paper itself

Abstract

Illustrated here is the development of a new class of antibiotic lead molecules targeted at

Indexed as

AcrylamideAnti-Bacterial AgentsBacterial ProteinsGlutaredoxinsHumansKineticsLeadModels, MolecularMolecular Docking SimulationMolecular StructureNuclear Magnetic Resonance, BiomolecularPseudomonas aeruginosaSmall Molecule LibrariesSpecies SpecificityStructure-Activity RelationshipAcrylamideAnti-Bacterial AgentsBacterial ProteinsGlutaredoxinsLeadSmall Molecule Librariesacrylamide warheadcovalent inhibitiondockingFBDDglutaredoxinHSQCSTDtrNOE

Identifiers

PMID31905878
PMCPMC6983068
OpenAlexW2997469296

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.