ArticleInternational journal of environmental research and public health2019
Increased Risk of Site-Specific Cancer in People with Type 2 Diabetes: A National Cohort Study.
Article in International journal of environmental research and public health, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 5 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 5 syntheses or guidelines pooled it, 28 citations in OpenAlex.
- Melanoma risk, tumour stage, and melanoma-specific mortality in individuals with diabetes: a systematic review and meta-analysis.BMC cancer · 2024Pooled it
- Marital status and risk of type 2 diabetes among middle-aged and elderly population: a systematic review and meta-analysis.Frontiers in medicine · 2024Pooled it
- Breast cancer risk for women with diabetes and the impact of metformin: A meta-analysis.Cancer medicine · 2023 · on this mapPooled it
- Different types of diabetes mellitus and risk of thyroid cancer: A meta-analysis of cohort studies.Frontiers in endocrinology · 2022Pooled it
- Diabetes mellitus and the risk of ovarian cancer: a systematic review and meta-analysis of cohort and case-control studies.BMJ open · 2020Pooled it
- Diabetes mellitus and the risk of vulvar and vaginal cancer: results from a large cohort study.BMC women's health · 2026Article
- Diabetes mellitus and the risk of ovarian cancer: an updated systematic review and meta-analysis of cohort and case-control studies.Diabetology & metabolic syndrome · 2025Review
- Body mass index and risk of connective and soft tissue cancer: results from a large cohort of 1.7 million individuals in Norway.BMC cancer · 2025Article
- The association between body mass index and vulvar and vaginal cancer incidence: findings from a large Norwegian cohort study.Cancer causes & control : CCC · 2025Article
- Therapeutic advances in type 1 myotonic dystrophy complicated with type 2 diabetes mellitus.Frontiers in neurology · 2025Review
- Effects of motivational interviewing intervention on psychological status, compliance behavior and quality of life of patients with malignant tumor combined with diabetes mellitus.Pakistan journal of medical sciences · 2024Article
- Serum tumor markers expression (CA199, CA242, and CEA) and its clinical implications in type 2 diabetes mellitus.World journal of diabetes · 2024Article
- Diabetes Mellitus and Thyroid Cancers: Risky Correlation, Underlying Mechanisms and Clinical Prevention.Diabetes, metabolic syndrome and obesity : targets and therapy · 2024Review
- Genetic association of type 2 diabetes and antidiabetic drug target with skin cancer.Frontiers in medicine · 2024Article
- The risk of cancer among insulin glargine users in Lithuania: A retrospective population-based study.Open medicine (Warsaw, Poland) · 2024Article
- Relationship between Changes in Blood Glucose and Blood Lipid Levels and the Risk of Thyroid Cancer in Patients with Type 2 Diabetes Mellitus.Disease markers · 2023Article
- Family cancer history and smoking habit associated with sarcoma in a Japanese population study.Scientific reports · 2022Article
- Cancer and diabetes co-occurrence: A national study with 44 million person-years of follow-up.PloS one · 2022Article
- Risk of Endometrial Cancer in Women with Diabetes: A Population-Based Retrospective Cohort Study.Journal of clinical medicine · 2021Article
- Trends in Incidence and Mortality of Primary Liver Cancer in Lithuania 1998-2015.International journal of environmental research and public health · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A retrospective cohort design was used with the objective to evaluate cancer risk among people with type 2 diabetes mellitus (T2DM) in Lithuania. The cohort was established by identifying all patients with the first diagnosis of T2DM in the National Health Insurance Fund database during 2000-2012. Cancer cases were identified by record linkage with the Lithuanian Cancer Registry. Standardized incidence ratios (SIRs) were calculated. Of the 127,290 people that were included, 5959 cases of cancer in men and 6661 cancer cases in women with T2DM were observed. A statistically significant increase in risk for all cancer sites was observed in women, SIR 1.16 (95% CI 1.14-1.19), but not in men, SIR 1.00 (95% CI 0.98-1.03). Among males, a significant increase of liver (SIR 2.11, 95% CI 1.79-2.49]), pancreas (SIR 1.77, 95% CI 1.57-1.99), kidney (SIR 1.46 95% CI 1.31-1.62), thyroid (SIR 1.83, 95% CI 1.32-2.54), colorectal (SIR 1.23, 95% CI 1.14-1.31]), skin melanoma (SIR 1.40, 95% CI 1.11-1.76), and non-melanoma skin (SIR 1.14, 95% CI 1.05-1.23) cancer was observed. For females with T2DM, a significant increase in risk of cancer of the liver (SIR 1.45, 95% CI 1.17-1.79), pancreas (SIR 1.74, 95% CI 1.56-1.93), kidney (SIR = 1.43, 95% CI 1.28-1.60), thyroid (SIR = 1.40, 95% CI 1.22-1.62), breast (SIR = 1.24, 95% CI 1.17-1.31), and corpus uteri (SIR 2.07, 95% CI 1.93-2.21) was observed. In conclusion, people with T2DM in Lithuania had an increased risk of site-specific cancer.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.