Evidence map›Paper›PMID 31905805›Full record

ArticleInternational journal of molecular sciences2019

Expression of Retinoid Acid Receptor-Responsive Genes in Rodent Models of Placental Pathology.

Alexander Mocker, Marius Schmidt, Hanna Huebner, Rainer Wachtveitl, Nada Cordasic, Carlos Menendez-Castro, Andrea Hartner, Fabian B Fahlbusch

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.6field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 7 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Alexander MockerDepartment of Pediatrics and Adolescent Medicine, Friedrich-Alexander University Erlangen-Nuremberg, 91054 Erlangen, Germany.
Marius SchmidtDepartment of Pediatrics and Adolescent Medicine, Friedrich-Alexander University Erlangen-Nuremberg, 91054 Erlangen, Germany.
Hanna HuebnerDepartment of Gynaecology and Obstetrics/Comprehensive Cancer Center Erlangen-EMN, Friedrich-Alexander University Erlangen-Nuremberg, 91054 Erlangen, Germany.ORCID 0000-0001-6889-1493
Rainer WachtveitlDepartment of Nephrology and Hypertension, Friedrich-Alexander University Erlangen-Nuremberg, 91054 Erlangen, Germany.
Nada CordasicDepartment of Nephrology and Hypertension, Friedrich-Alexander University Erlangen-Nuremberg, 91054 Erlangen, Germany.
Carlos Menendez-CastroDepartment of Pediatrics and Adolescent Medicine, Friedrich-Alexander University Erlangen-Nuremberg, 91054 Erlangen, Germany.
Andrea HartnerDepartment of Pediatrics and Adolescent Medicine, Friedrich-Alexander University Erlangen-Nuremberg, 91054 Erlangen, Germany.
Fabian B FahlbuschDepartment of Pediatrics and Adolescent Medicine, Friedrich-Alexander University Erlangen-Nuremberg, 91054 Erlangen, Germany.
Friedrich-Alexander-Universität Erlangen-Nürnberg · DEComprehensive Cancer Center Erlangen · DE

Funding

Deutsche Forschungsgemeinschaft Funding programme: Open Access Publishing
6 · The paper itself

Abstract

In humans, retinoic acid receptor responders (RARRES) have been shown to be altered in third trimester placentas complicated by the pathologies preeclampsia (PE) and PE with intrauterine growth restriction (IUGR). Currently, little is known about the role of placental Rarres in rodents. Therefore, we examined the localization and expression of Rarres1 and 2 in placentas obtained from a Wistar rat model of isocaloric maternal protein restriction (E18.5, IUGR-like features) and from an eNOS-knockout mouse model (E15 and E18.5, PE-like features). In both rodent models, Rarres1 and 2 were mainly localized in the placental spongiotrophoblast and giant cells. Their placental expression, as well as the expression of the Rarres2 receptor chemokine-like receptor 1 (

Indexed as

AnimalsChemokinesFemaleFetal Growth RetardationIntercellular Signaling Peptides and ProteinsInterleukin-11Membrane ProteinsMiceMice, Inbred C57BLMice, KnockoutPlacentaPre-EclampsiaPregnancyRatsRats, WistarReceptors, Chemokinechemerin protein, mouseChemokinesCMKLR1 protein, mouseCmklr1 protein, ratIntercellular Signaling Peptides and ProteinsInterleukin-11Membrane ProteinsRarres1 protein, mouseRarres1 protein, ratRarres2 protein, ratReceptors, ChemokineReceptors, Retinoic AcidchemerinCmklR1eNOS-knockoutIL-11IUGRlow protein dietPEplacentapregnancyRARRES

Identifiers

PMID31905805
PMCPMC6981780
OpenAlexW2997138050

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.