Evidence map›Paper›PMID 31905768›Full record

ArticleInternational journal of molecular sciences2019

Establishment and Characterization of a Murine Mucosal Mast Cell Culture Model.

Aya Kakinoki, Tsuyoshi Kameo, Shoko Yamashita, Kazuyuki Furuta, Satoshi Tanaka

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.4field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 7 citations in OpenAlex.

  1. Fibrates : Do They Still Have a Role in Therapy in 2025?Current atherosclerosis reports · 2025
    Review
  2. Article
  3. Article
  4. Article
  5. Increased miR-21-3p and miR-487b-3p serum levels during anaphylactic reaction in food allergic children.Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology · 2021
    Article
  6. Article
  7. Phenotypic and Functional Diversity of Mast Cells.International journal of molecular sciences · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Aya KakinokiDepartment of Immunobiology, Faculty of Pharmacy and Pharmaceutical Sciences, Okayama University, Tsushima naka 1-1-1, Kita-ku, Okayama 700-8530, Japan.
Tsuyoshi KameoDepartment of Immunobiology, Faculty of Pharmacy and Pharmaceutical Sciences, Okayama University, Tsushima naka 1-1-1, Kita-ku, Okayama 700-8530, Japan.
Shoko YamashitaDepartment of Immunobiology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Tsushima naka 1-1-1, Kita-ku, Okayama 700-8530, Japan.
Kazuyuki FurutaDepartment of Immunobiology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Tsushima naka 1-1-1, Kita-ku, Okayama 700-8530, Japan.
Satoshi TanakaDepartment of Pharmacology, Division of Pathological Sciences, Kyoto Pharmaceutical University, Misasagi Nakauchi-cho 5, Yamashina-ku, Kyoto 607-8414, Japan.ORCID 0000-0002-3468-7694
Okayama University · JPKyoto Pharmaceutical University · JP

Funding

Japan Society for the Promotion of Science 16K08231Japan Society for the Promotion of Science 23590077
6 · The paper itself

Abstract

Accumulating evidence suggests that mast cells play critical roles in disruption and maintenance of intestinal homeostasis, although it remains unknown how they affect the local microenvironment. Interleukin-9 (IL-9) was found to play critical roles in intestinal mast cell accumulation induced in various pathological conditions, such as parasite infection and oral allergen-induced anaphylaxis. Newly recruited intestinal mast cells trigger inflammatory responses and damage epithelial integrity through release of a wide variety of mediators including mast cell proteases. We established a novel culture model (IL-9-modified mast cells, MCs/IL-9), in which murine IL-3-dependent bone-marrow-derived cultured mast cells (BMMCs) were further cultured in the presence of stem cell factor and IL-9. In MCs/IL-9, drastic upregulation of

Indexed as

Adenosine TriphosphateAnimalsBone Marrow CellsCell Culture TechniquesCell DegranulationCells, CulturedChymasesHistamineImmunoglobulin EInterleukin-3Interleukin-9Mast CellsMiceMice, Inbred BALB CModels, BiologicalStem Cell FactorAdenosine Triphosphatechymase 2ChymasesHistamineImmunoglobulin EInterleukin-3Interleukin-9Mcpt1 protein, mouseStem Cell FactorATPchymasehistamineIL-9mast cell

Identifiers

PMID31905768
PMCPMC6982154
OpenAlexW2982635577

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.