Evidence map›Paper›PMID 31905754›Full record

ArticleCells2019

Upregulation of Epithelial-To-Mesenchymal Transition Markers and P2X7 Receptors Is Associated to Increased Invasiveness Caused by P2X7 Receptor Stimulation in Human Glioblastoma Stem Cells.

Sihana Ziberi, Mariachiara Zuccarini, Marzia Carluccio, Patricia Giuliani, Lucia Ricci-Vitiani, Roberto Pallini, Francesco Caciagli, Patrizia Di Iorio, Renata Ciccarelli

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cells, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed
3.5field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 40 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Review
  5. Purinergic system in cancer stem cells.Purinergic signalling · 2025
    Review
  6. P2X7 Variants in Pathophysiology.International journal of molecular sciences · 2024
    Review
  7. Article
  8. Review
  9. Review
  10. Review
  11. Early Dry Eye Disease Onset in a NOD.H-2h4 Mouse Model of Sjögren's Syndrome.Investigative ophthalmology & visual science · 2022
    Article
  12. Article
  13. Review
  14. Article
  15. Article
  16. Article
  17. Article
  18. Review
  19. P2X7 receptor: a critical regulator and potential target for breast cancer.Journal of molecular medicine (Berlin, Germany) · 2021
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Sihana ZiberiDepartment of Medical, Oral and Biotechnological Sciences, University of Chieti-Pescara, Via dei Vestini 29, 66100 Chieti, Italy.
Mariachiara ZuccariniDepartment of Medical, Oral and Biotechnological Sciences, University of Chieti-Pescara, Via dei Vestini 29, 66100 Chieti, Italy.
Marzia CarluccioDepartment of Medical, Oral and Biotechnological Sciences, University of Chieti-Pescara, Via dei Vestini 29, 66100 Chieti, Italy.
Patricia GiulianiDepartment of Medical, Oral and Biotechnological Sciences, University of Chieti-Pescara, Via dei Vestini 29, 66100 Chieti, Italy.
Lucia Ricci-VitianiDepartment of Oncology and Molecular Medicine, Istituto Superiore di Sanità, Via Regina Elena 299, 00161 Rome, Italy.
Roberto PalliniInstitute of Neurosurgery, Università Cattolica del Sacro Cuore, Largo Agostino Gemelli 8, 00168 Rome, Italy.
Francesco CaciagliCenter for Advanced Study and Technologies (CAST). University of Chieti-Pescara, Via L. Polacchi, 66100 Chieti, Italy.
Patrizia Di IorioDepartment of Medical, Oral and Biotechnological Sciences, University of Chieti-Pescara, Via dei Vestini 29, 66100 Chieti, Italy.
Renata CiccarelliDepartment of Medical, Oral and Biotechnological Sciences, University of Chieti-Pescara, Via dei Vestini 29, 66100 Chieti, Italy.ORCID 0000-0003-1412-738X
University of Chieti-Pescara · ITIstituto Superiore di Sanità · ITUniversità Cattolica del Sacro Cuore · IT

Funding

University of Chieti-Pescara AT2018CICCARELLI
6 · The paper itself

Abstract

Glioblastoma (GBM) stem cells (GSCs), which contribute to GBM unfavorable prognosis, show high expression levels of ATP/P2X7 receptors (P2X7R). Here, we reported that cells exposure to 2'(3')-

Indexed as

Gene Expression Regulation, NeoplasticBiomarkersCell Line, TumorCell MovementCell SurvivalEpithelial-Mesenchymal TransitionGlioblastomaHumansNeoplasm InvasivenessNeoplastic Stem CellsPhosphorylationReceptors, Purinergic P2X7Signal TransductionTransforming Growth Factor beta1Tumor MicroenvironmentBiomarkersReceptors, Purinergic P2X7TGFB1 protein, humanTransforming Growth Factor beta1BzATPepithelial-to-mesenchymal transition (EMT) markersglioblastoma stem cells (GSCs)GSC invasivenessP2X7 receptor splice variants A and Btransforming growth factor beta

Identifiers

PMID31905754
PMCPMC7016938
OpenAlexW2998642141

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.