Evidence map›Paper›PMID 31905734›Full record

ArticleAnimals : an open access journal from MDPI2019

A Novel SNPs in Alpha-Lactalbumin Gene Effects on Lactation Traits in Chinese Holstein Dairy Cows.

Fan Yang, Manling Zhang, Yuewen Rong, Zaiqun Liu, Shuai Yang, Wei Zhang, Jun Li, Yafei Cai

Open access · goldAbstract read
In one paragraph

Article in Animals : an open access journal from MDPI, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.1field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Identification of the BovineAnimals : an open access journal from MDPI · 2025
    Article
  5. Article
  6. Article
  7. Polymorphisms ofAnimals : an open access journal from MDPI · 2021
    Article
  8. Article
  9. Review
  10. Functional Analysis of Haplotypes in BovineAnimals : an open access journal from MDPI · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Fan YangCollege of Animal Science and Technology, Nanjing Agricultural University, Nanjing 210095, China.ORCID 0000-0002-4123-0836
Manling ZhangCollege of Animal Science and Technology, Nanjing Agricultural University, Nanjing 210095, China.
Yuewen RongPhysical and chemical testing laboratory, Anji County Center for Food and Drug Control, Huzhou 313300, China.
Zaiqun LiuCollege of Life Sciences, Anhui Provincial Key Lab of the Conservation and Exploitation of Biological Resources, Anhui Normal University, Wuhu 241000, China.
Shuai YangCollege of Life Sciences, Anhui Provincial Key Lab of the Conservation and Exploitation of Biological Resources, Anhui Normal University, Wuhu 241000, China.
Wei ZhangCollege of Animal Science and Technology, Nanjing Agricultural University, Nanjing 210095, China.ORCID 0000-0002-8359-6668
Jun LiCollege of Life Sciences, Anhui Provincial Key Lab of the Conservation and Exploitation of Biological Resources, Anhui Normal University, Wuhu 241000, China.
Yafei CaiCollege of Animal Science and Technology, Nanjing Agricultural University, Nanjing 210095, China.
Nanjing Agricultural University · CNAnhui Normal University · CN

Funding

National Key R&D Program of China 2018YFC1200201Start-up grant from Nanjing Agricultural University 804090This study was supported by Agricultural Innovation fund of Jiangsu Province CX (18)3014
6 · The paper itself

Abstract

Alpha-lactalbumin (α-LA) is a major whey protein in bovine and other mammalian milk, which regulates synthesis of lactose. Little is known about its genetic polymorphism and whether can be used as a potential marker for dairy ingredients, milk yield traits, and milk properties. To investigate its polymorphisms and their relationship with milk lactation traits in Chinese Holstein dairy cows, single-strand conformation polymorphism method (PCR-SSCP) and direct sequencing method were used to mark the α-LA gene SNPs. AA (0.7402) and AB (0.2598) genotypes were screened out by PCR-SSCP bands analysis in two independent populations. Direct sequencing revealed that there is one SNP at 1847th (T/C) bp in noncoding region of α-LA gene with highly polymorphic (0.5 < PIC = 0.5623 or 0.5822), of which T is in AA genotype while C in AB. Association analysis also showed that lactose content (

Indexed as

Alpha-lactalbumin (α-LA)Chinese Holstein dairy cowslactosePCR-SSCPSNPs

Identifiers

PMID31905734
PMCPMC7023285
OpenAlexW2996826861

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.