ReviewNutrients2019
Intestinal Fructose and Glucose Metabolism in Health and Disease.
Review in Nutrients, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 70 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
70 citing papers in PubMed, 1 synthesis or guideline pooled it, 127 citations in OpenAlex.
- Chronic Fructose Substitution for Glucose or Sucrose in Food or Beverages and Metabolic Outcomes: An Updated Systematic Review and Meta-Analysis.Frontiers in nutrition · 2021Pooled it
- Acute glycaemic response of orange juice consumption with breakfast in individuals with type 2 diabetes: a randomized cross-over trial.Nutrition & diabetes · 2025Trial
- Methanogenesis associated with altered microbial production of short-chain fatty acids and human-host metabolizable energy.The ISME journal · 2025Trial
- Article
- Maternal Isocaloric Monosaccharide Diets Reorganize Dorsal-Ventral Hippocampal Maturation and Ventral Plasticity in Rat Offspring.Cellular and molecular neurobiology · 2026Article
- SGLT1 and SGLT2 Modulation in Antidiabetic Therapy-Comparative Insights into Gliflozins and Natural Compounds Resveratrol and Viniferin.Pharmaceuticals (Basel, Switzerland) · 2026Review
- Free Sugars Consumption and Type 2 Diabetes: What Are the Concerns and How Strong is the Evidence?Current nutrition reports · 2026Review
- Article
- Fructose metabolism as an adaptive survival axis in pancreatic cancer: mechanistic insights and therapeutic implications.Frontiers in medicine · 2026Review
- Monocyte Preprogramming by Tobacco Carcinogens and Fructose Intake Accelerates Lung Cancer Progression via Metabolic and Epigenetic Pathways.International journal of biological sciences · 2026Article
- Maternal monosaccharide diets modulate melanocortin-4 receptor signaling and metabolic state in rat offspring.Pharmacological reports : PR · 2025Article
- Who Likes Sweets? Sweet Patterns: Influence of Sex, Age, Body Mass Index, Smoking and Olfactory Efficiency on the Consumption of Sweet Products.Nutrients · 2025Article
- Metabolomics reveals the hindgut metabolic changes and physiological impacts in weaned piglets subjected to ETEC infection and berberine intervention.Scientific reports · 2025Article
- Glycemic and Insulinemic Index Values of Apple Puree.Food science & nutrition · 2025Article
- Narrative review of metabolic syndrome and its relationships with non-alcoholic fatty liver disease, gonadal dysfunction and obstructive sleep apnea.Diabetology & metabolic syndrome · 2025Review
- Review
- Comparing the Effects of Glucose-Fructose versus Glucose on the Oxidation Rate: A Systematic Review and Meta-Analysis.Iranian journal of public health · 2025Review
- Fructose induces inflammatory activation in macrophages and microglia through the nutrient-sensing ghrelin receptor.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2025Article
- Fructose Metabolism in Cancer: Molecular Mechanisms and Therapeutic Implications.International journal of medical sciences · 2025Review
- Ramipril and ketogenic diet response in cognitive dysfunction of insulin-resistant rats.Frontiers in pharmacology · 2025Article
10 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
The worldwide epidemics of obesity and diabetes have been linked to increased sugar consumption in humans. Here, we review fructose and glucose metabolism, as well as potential molecular mechanisms by which excessive sugar consumption is associated to metabolic diseases and insulin resistance in humans. To this end, we focus on understanding molecular and cellular mechanisms of fructose and glucose transport and sensing in the intestine, the intracellular signaling effects of dietary sugar metabolism, and its impact on glucose homeostasis in health and disease. Finally, the peripheral and central effects of dietary sugars on the gut-brain axis will be reviewed.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.