ReviewAntioxidants (Basel, Switzerland)2019
Exposure to Toxic Heavy Metals Can Influence Homocysteine Metabolism?
Review in Antioxidants (Basel, Switzerland), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 44 citations in OpenAlex.
- Follicular homocysteine as a marker of oocyte quality in PCOS and the role of micronutrients.Journal of assisted reproduction and genetics · 2023Trial
- Causal effects between blood metabolites and myocardial infarction: A 2-sample Mendelian randomization study.Medicine · 2026Article
- Associations between prenatal metal exposure, gene variants, and birth size in Taiwan Birth Panel Study.Pediatric research · 2026Article
- Organ-specific apoptotic pathways induced by micro- and nanoplastics: a systematic review ofFrontiers in toxicology · 2026Review
- Tracking biochemical indicators of air pollution exposure in acute cardiorespiratory emergencies: a scoping review.Frontiers in public health · 2026Article
- Astaxanthin Alleviates Lead-Induced Toxicity by Restoring Hepatic and Gut-Liver Axis Homeostasis Through Multidimensional Metabolic and Antioxidative Pathways.Food science & nutrition · 2025Article
- Review
- Article
- Article
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- Association of plasma homocysteine with cardiometabolic multimorbidity: a cross-sectional study in northwest China.Lipids in health and disease · 2024Article
- Hyperhomocysteinemia Is Associated With a Myriad of Age-Related Illnesses: A Potential Role for Metal Toxicity.Mayo Clinic proceedings · 2024Article
- First trimester prenatal metal mixtures, vitamins, and hypertensive disorders of pregnancy in the project viva cohort.Environment international · 2024Article
- Metabolomic changes in children with autism.World journal of clinical pediatrics · 2024Article
- Article
- Biochemical and Hematological Markers in Workers with Chronical Exposure to Lead and Cadmium in Colombia.Toxics · 2022Article
- Article
- Detrimental health relationship between blood lead and cadmium and the red blood cell folate level.Scientific reports · 2022Article
- Associations between Plasma Folate and Vitamin BNutrients · 2022Observational
- Esophageal cancer and bacterial part of gut microbiota - A multidisciplinary point of view.Frontiers in cellular and infection microbiology · 2022Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundHomocysteine is a sulfur amino acid whose metabolism is activated in two pathways: remethylation to methionine, which requires folate and vitamin B
methodsA systematic review was carried out to clarify the relationship between homocysteine blood levels and exposure to toxic heavy metals (Lead, Cadmium, Mercury, and Chromium).
resultsThe results of this systematic review indicate that exposure to Pb, Cr, Cd, and Hg is connected with nonphysiological homocysteine levels or vitamin B
conclusionsThese findings reinforce the importance of involvement in exposure to heavy metals in homocysteine metabolism. This supports the role of blood metals as potential upstream modifiable risk factors to prevent the development of other established risk factors as hyperhomocysteinemia.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.