Evidence map›Paper›PMID 31905672›Full record

ArticleInternational journal of molecular sciences2019

Proteomic Analyses Reveal New Insights on the Antimicrobial Mechanisms of Chitosan Biopolymers and Their Nanosized Particles against

Laidson P Gomes, Sandra I Anjo, Bruno Manadas, Ana V Coelho, Vania M F Paschoalin

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.7field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 14 citations in OpenAlex.

  1. Species-Specific Stress Responses to Selenium Nanoparticles inNanomaterials (Basel, Switzerland) · 2025
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 2 countries.

Laidson P GomesChemistry Institute, Federal University of Rio de Janeiro, Avenida Athos da Silveira Ramos 149, Rio de Janeiro 21949-909, RJ, Brazil.ORCID 0000-0002-7096-5380
Sandra I AnjoCNC-Center for Neuroscience and Cell Biology, University of Coimbra, Rua Larga, 3004-504 Coimbra, Portugal.ORCID 0000-0003-2180-3518
Bruno ManadasCNC-Center for Neuroscience and Cell Biology, University of Coimbra, Rua Larga, 3004-504 Coimbra, Portugal.ORCID 0000-0002-2087-4042
Ana V CoelhoInstituto de Tecnologia Química e Biológica, Universidade Nova de Lisboa, Av. da Republica, 2780-157 Oeiras, Portugal.ORCID 0000-0002-6143-4203
Vania M F PaschoalinChemistry Institute, Federal University of Rio de Janeiro, Avenida Athos da Silveira Ramos 149, Rio de Janeiro 21949-909, RJ, Brazil.
Universidade Federal do Rio de Janeiro · BRUniversity of Coimbra · PTUniversidade Nova de Lisboa · PT

Funding

Lacrimal Gland Repair Using Progenitor CellsR01EY026202 · NEI · SCRIPPS RESEARCH INSTITUTE, THE · PI MAKARENKOVA, HELEN P. · 2016 to 2025
$5.2M
STUDIES OF RETINITIS PIGMENTOSA AND ALLIED DISEASESU01EY002014 · NEI · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI BERSON, ELIOT L · 1988 to 1989
–
COMMUNITY CLINICAL ONCOLOGY PROGRAMU10CA035441 · NCI · CHARLESTON AREA MED CTR (CHARLESTON, WV) · PI JUBELIRER, STEVEN · 1985 to 1989
–
STUDIES OF RETINITIS PIGMENTOSA AND ALLIED DISEASESU10EY002014 · NEI · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI BERSON, ELIOT L · 1990 to 1993
–
European Regional Development Fund LISBOA-01-0145-FEDER-007660Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro E-26/010.002673/2014Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro E-26/010002864/2014Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro E-26/202.815/2018Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro E-26/203.039/2015Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro PDR-10-E-26/202.319/2017Fundação para a Ciência e a Tecnologia ICI35441Fundos Europeus Estruturais e de Investimento - FEEI LISBOA-01-0145-FEDER-016417
6 · The paper itself

Abstract

The well-known antimicrobial effects of chitosan (CS) polymers make them a promising adjuvant in enhancing antibiotic effectiveness against human pathogens. However, molecular CS antimicrobial mechanisms remain unclear, despite the insights presented in the literature. Thus, the aim of the present study was to depict the molecular effects implicated in the interaction of low or medium molecular mass CS polymers and their nanoparticle-counterparts against

Indexed as

Anti-Bacterial AgentsBacterial Outer Membrane ProteinsChitosanEscherichia coliNanoparticlesProteomeAnti-Bacterial AgentsBacterial Outer Membrane ProteinsChitosanProteomeantibiotic effectanti-microbial molecular mechanismchitosan polymergene ontologyKEGGmetaboanalystmicro-LC-MS/MSSTRING analysisultrasonicated-cs nanoparticles

Identifiers

PMID31905672
PMCPMC6981525
OpenAlexW2997960030

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.