Evidence map›Paper›PMID 31905670›Full record

ArticleBiomedicines2019

Comprehensive Analysis of Neurotoxin-Induced Ablation of Dopaminergic Neurons in Zebrafish Larvae.

Michael Kalyn, Khang Hua, Suzita Mohd Noor, Chee Ern David Wong, Marc Ekker

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomedicines, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
3.5field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 68 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

Michael KalynDepartment of Biology, Faculty of Science, University of Ottawa, ON K1N 6N5, Canada.
Khang HuaDepartment of Biology, Faculty of Science, University of Ottawa, ON K1N 6N5, Canada.ORCID 0000-0001-8808-2941
Suzita Mohd NoorDepartment of Biomedical Science, Faculty of Medicine, University of Malaya, Kuala Lumpur 50603, Malaysia.
Chee Ern David WongDepartment of Biomedical Science, Faculty of Medicine, University of Malaya, Kuala Lumpur 50603, Malaysia.
Marc EkkerDepartment of Biology, Faculty of Science, University of Ottawa, ON K1N 6N5, Canada.
University of Ottawa · CAUniversity of Malaya · MY

Funding

Natural Sciences and Engineering Research Council of Canada 121795
6 · The paper itself

Abstract

Neurotoxin exposure of zebrafish larvae has been used to mimic a Parkinson's disease (PD) phenotype and to facilitate high-throughput drug screening. However, the vulnerability of zebrafish to various neurotoxins was shown to be variable. Here, we provide a direct comparison of ablative effectiveness in order to identify the optimal neurotoxin-mediated dopaminergic (DAnergic) neuronal death in larval zebrafish. Transgenic zebrafish, Tg(

Indexed as

dopaminergic neuronslocomotorneurotoxinsParkinson’s diseaseventral diencephalonzebrafish

Identifiers

PMID31905670
PMCPMC7168159
OpenAlexW2998443696

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.