Evidence map›Paper›PMID 31905636›Full record

ArticleBrain sciences2019

Haptoglobin Hp1 Variant Does Not Associate with Small Vessel Disease.

Juha Lempiäinen, Petra Ijäs, Teemu J Niiranen, Markku Kaste, Pekka J Karhunen, Perttu J Lindsberg, Timo Erkinjuntti, Susanna Melkas

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Brain sciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 46% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

Juha LempiäinenClinical Neurosciences, University of Helsinki, 00014 Helsinki, Finland.
Petra IjäsClinical Neurosciences, University of Helsinki, 00014 Helsinki, Finland.
Teemu J NiiranenDepartment of Public Health Solutions, National institute for Health and Welfare, Mannerheimintie 166, 00300 Helsinki, Finland.
Markku KasteClinical Neurosciences, University of Helsinki, 00014 Helsinki, Finland.
Pekka J KarhunenSchool of Medicine, University of Tampere, 33014 Tampere, Finland.
Perttu J LindsbergClinical Neurosciences, University of Helsinki, 00014 Helsinki, Finland.
Timo ErkinjunttiClinical Neurosciences, University of Helsinki, 00014 Helsinki, Finland.
Susanna MelkasClinical Neurosciences, University of Helsinki, 00014 Helsinki, Finland.
University of Helsinki · FIHelsinki University Hospital · FITampere University · FIUniversity of Turku · FI

Funding

Aarne Koskelon Säätiö 10000Helsinki and Uusimaa Research Grants 10000Jane ja Aatos Erkon Säätiö 10000Maire Taposen Säätiö 2500Orionin Tutkimussäätiö 10000Paavo Nurmen Säätiö 10000Päivikki and Sakari Sohlberg Foundation 10000Paulon Säätiö 10000Sigrid Juséliuksen Säätiö 10000Suomen Lääketieteen Säätiö 10000
6 · The paper itself

Abstract

Haptoglobin (Hp) is a plasma protein that binds free hemoglobin and protects tissues from oxidative damage. An Hp2 allele has been associated with an increased risk of cardiovascular complications. On the other hand, recent studies have suggested that Hp1 allele increases risk to develop severe cerebral small vessel disease. We aimed to replicate this finding in a first-ever stroke patient cohort. Hp was genotyped by PCR and gel electrophoresis in the Helsinki Stroke Aging Memory Study in patients with DNA and magnetic resonance imaging (MRI) available (SAM;

Indexed as

haptoglobinslacunar infarctsmall vessel disease (SVD)white matter lesions (WML)

Identifiers

PMID31905636
PMCPMC7016682
OpenAlexW2997285199

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.