Evidence map›Paper›PMID 31905366›Full record

ArticleNature2020

The structural basis for cohesin-CTCF-anchored loops.

Yan Li, Judith H I Haarhuis, Ángela Sedeño Cacciatore, Roel Oldenkamp, Marjon S van Ruiten, Laureen Willems, Hans Teunissen, Kyle W Muir, Elzo de Wit, Benjamin D Rowland and 1 more

Open access · greenAbstract read
In one paragraph

Article in Nature, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 279 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
279citing papers in PubMed, 1 pooled it
25.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

279 citing papers in PubMed, 1 synthesis or guideline pooled it, 488 citations in OpenAlex.

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  15. Current Challenges of Transcription Compartmentalization Research.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Review
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  20. Article

219 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 3 countries.

Yan Li *European Molecular Biology Laboratory, Grenoble, France.
Judith H I Haarhuis *Division of Gene Regulation, The Netherlands Cancer Institute, Amsterdam, The Netherlands.
Ángela Sedeño Cacciatore *Division of Gene Regulation, The Netherlands Cancer Institute, Amsterdam, The Netherlands.
Roel OldenkampDivision of Gene Regulation, The Netherlands Cancer Institute, Amsterdam, The Netherlands.
Marjon S van RuitenDivision of Gene Regulation, The Netherlands Cancer Institute, Amsterdam, The Netherlands.
Laureen WillemsDivision of Gene Regulation, The Netherlands Cancer Institute, Amsterdam, The Netherlands.
Hans TeunissenDivision of Gene Regulation, Oncode Institute, The Netherlands Cancer Institute, Amsterdam, The Netherlands.
Kyle W MuirEuropean Molecular Biology Laboratory, Grenoble, France. kmuir@mrc-lmb.cam.ac.uk.
Elzo de WitDivision of Gene Regulation, Oncode Institute, The Netherlands Cancer Institute, Amsterdam, The Netherlands. e.d.wit@nki.nl.
Benjamin D RowlandDivision of Gene Regulation, The Netherlands Cancer Institute, Amsterdam, The Netherlands. b.rowland@nki.nl.
Daniel PanneEuropean Molecular Biology Laboratory, Grenoble, France. daniel.panne@le.ac.uk.
Oncode Institute · NLThe Netherlands Cancer Institute · NLEuropean Molecular Biology Laboratory · FRMRC Laboratory of Molecular Biology · GBUniversity of Leicester · GB

Funding

European Research Council 637587
6 · The paper itself

Abstract

Cohesin catalyses the folding of the genome into loops that are anchored by CTCF

Indexed as

Binding SitesCarrier ProteinsCCCTC-Binding FactorCell Cycle ProteinsChromatinChromosomal Proteins, Non-HistoneCohesinsCrystallography, X-RayDNAHumansLigandsModels, MolecularNuclear ProteinsPeptide FragmentsProtein BindingProtein StabilityCarrier ProteinsCCCTC-Binding FactorCell Cycle ProteinsChromatinChromosomal Proteins, Non-HistoneCohesinsCTCF protein, humanDNALigandsNuclear ProteinsPeptide FragmentsProtein SubunitsProto-Oncogene ProteinsWAPL protein, human

Identifiers

PMID31905366
PMCPMC7035113
OpenAlexW2998399076

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.