Evidence map›Paper›PMID 31904975›Full record

ArticleNano letters2020

Silicon Nanowires for Intracellular Optical Interrogation with Subcellular Resolution.

Menahem Y Rotenberg, Benayahu Elbaz, Vishnu Nair, Erik N Schaumann, Naomi Yamamoto, Nivedina Sarma, Laura Matino, Francesca Santoro, Bozhi Tian

Abstract read
In one paragraph

Article in Nano letters, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
  6. Review
  7. Article
  8. Article
  9. Review
  10. Nanoenabled Bioelectrical Modulation.Accounts of materials research · 2021
    Article
  11. Article
  12. Article
  13. Article
  14. On the Interaction between 1D Materials and Living Cells.Journal of functional biomaterials · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Menahem Y Rotenberg
Benayahu Elbaz
Vishnu Nair
Erik N Schaumann
Naomi Yamamoto
Nivedina Sarma
Laura MatinoTissue Electronics, Center for Advanced Biomaterials for Healthcare , Istituto Italiano di Tecnologia , 80125 Naples , Italy.
Francesca SantoroTissue Electronics, Center for Advanced Biomaterials for Healthcare , Istituto Italiano di Tecnologia , 80125 Naples , Italy.ORCID 0000-0001-7323-9504

Funding

ZFP24 Control of the myelination program of oligodendrocytesR01NS067550 · NINDS · UNIVERSITY OF CHICAGO · PI ELBAZ-EILON, BENAYAHU · 2009 to 2024
$3.4M
Silicon-based Injectable Micro-gels for Non-genetic and Wireless Modulation of Neurons, Cardiomyocytes and Neuromuscular SystemDP2NS101488 · NINDS · UNIVERSITY OF CHICAGO · PI TIAN, BOZHI · 2016 to 2016
$2.4M
NINDS NIH HHS DP2 NS101488NINDS NIH HHS R01 NS067550
6 · The paper itself

Abstract

Current techniques for intracellular electrical interrogation are limited by substrate-bound devices, technically demanding methods, or insufficient spatial resolution. In this work, we use freestanding silicon nanowires to achieve photoelectric stimulation in myofibroblasts with subcellular resolution. We demonstrate that myofibroblasts spontaneously internalize silicon nanowires and subsequently remain viable and capable of mitosis. We then show that stimulation of silicon nanowires at separate intracellular locations results in local calcium fluxes in subcellular regions. Moreover, nanowire-myofibroblast hybrids electrically couple with cardiomyocytes in coculture, and photostimulation of the nanowires increases the spontaneous activation rate in coupled cardiomyocytes. Finally, we demonstrate that this methodology can be extended to the interrogation of signaling in neuron-glia interactions using nanowire-containing oligodendrocytes.

Indexed as

AnimalsCalciumCytoplasmMitosisMyocytes, CardiacNanowiresNeuronsOligodendrogliaRatsSignal TransductionSiliconCalciumSiliconbiological modulationintracellularmyofibroblastsoligodendrocytesSilicon nanowires

Identifiers

PMID31904975
PMCPMC7513588

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.