ArticleHuman brain mapping2020
Cortical lesions causing loss of consciousness are anticorrelated with the dorsal brainstem.
Article in Human brain mapping, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
42 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Human lesions and animal studies link the claustrum to perception, salience, sleep and pain.Brain : a journal of neurology · 2022Pooled it
- Early effect of thrombolysis on structural brain network organisation after anterior-circulation stroke in the randomized WAKE-UP trial.Human brain mapping · 2022Trial
- A lesion-derived brain network of somatic symptoms for transdiagnostic individual application.BMC medicine · 2026Article
- Supratentorial Brain Lesions in Unconscious Patients Map to a Common Human Brain Circuit.Annals of neurology · 2026Observational
- Neuroimaging of Disorder of Consciousness: From Brain Network Mechanisms to Clinical Translation.Journal of clinical neurology (Seoul, Korea) · 2026Review
- Reflections on Consciousness in Intensive Care.Acta paediatrica (Oslo, Norway : 1992) · 2026Review
- Automated MRI Segmentation of Brainstem Nuclei Critical to Consciousness.Human brain mapping · 2025Observational
- Subcortical Hubs of Brain Networks Sustaining Human Consciousness.Human brain mapping · 2025Article
- Hidden Structures: Gap Junctions, the Claustrum, and Anesthesia.Anesthesia and analgesia · 2025Article
- Multimodal state-dependent connectivity analysis of arousal and autonomic centers in the brainstem and basal forebrain.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Article
- Automated Measurement of Cerebral Hemorrhagic Contusions and Outcomes After Traumatic Brain Injury in the TRACK-TBI Study.JAMA network open · 2024Article
- Localization of stuttering based on causal brain lesions.Brain : a journal of neurology · 2024Article
- The Constrained Disorder Principle May Account for Consciousness.Brain sciences · 2024Review
- Neuroimaging in Disorders of Consciousness and Recovery.Physical medicine and rehabilitation clinics of North America · 2024Review
- Common Data Elements for Disorders of Consciousness: Recommendations from the Working Group on Neuroimaging.Neurocritical care · 2023Article
- Injury patterns associated with cognitive motor dissociation.Brain : a journal of neurology · 2023Article
- Using predictive validity to compare associations between brain damage and behavior.Human brain mapping · 2023Article
- The biomechanical signature of loss of consciousness: computational modelling of elite athlete head injuries.Brain : a journal of neurology · 2023Review
- The Current of Consciousness: Neural Correlates and Clinical Aspects.Current neurology and neuroscience reports · 2023Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
Abstract
Brain lesions can provide unique insight into the neuroanatomical substrate of human consciousness. For example, brainstem lesions causing coma map to a specific region of the tegmentum. Whether specific lesion locations outside the brainstem are associated with loss of consciousness (LOC) remains unclear. Here, we investigate the topography of cortical lesions causing prolonged LOC (N = 16), transient LOC (N = 91), or no LOC (N = 64). Using standard voxel lesion symptom mapping, no focus of brain damage was associated with LOC. Next, we computed the network of brain regions functionally connected to each lesion location using a large normative connectome dataset (N = 1,000). This technique, termed lesion network mapping, can test whether lesions causing LOC map to a connected brain circuit rather than one brain region. Connectivity between cortical lesion locations and an a priori coma-specific region of brainstem tegmentum was an independent predictor of LOC (B = 1.2, p = .004). Connectivity to the dorsal brainstem was the only predictor of LOC in a whole-brain voxel-wise analysis. This relationship was driven by anticorrelation (negative correlation) between lesion locations and the dorsal brainstem. The map of regions anticorrelated to the dorsal brainstem thus defines a distributed brain circuit that, when damaged, is most likely to cause LOC. This circuit showed a slight posterior predominance and had peaks in the bilateral claustrum. Our results suggest that cortical lesions causing LOC map to a connected brain circuit, linking cortical lesions that disrupt consciousness to brainstem sites that maintain arousal.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.