SynthesisThe review of diabetic studies : RDS2019
Application of Topical Oxygen Therapy in Healing Dynamics of Diabetic Foot Ulcers - A Systematic Review.
Synthesis in The review of diabetic studies : RDS, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05427760 (Effect of Using Oxygen on the Diaper Dermatitis in Infants), which is not on this map. Cited by 12 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Effect of Using Oxygen on the Diaper Dermatitis in Infants
Who cites it
12 citing papers in PubMed, 2 syntheses or guidelines pooled it, 26 citations in OpenAlex.
- Efficacy of Topical Wound Oxygen Therapy in Healing Chronic Diabetic Foot Ulcers: Systematic Review and Meta-Analysis.Advances in wound care · 2023Pooled it
- Efficacy and safety of topical oxygen therapy for diabetic foot ulcers: An updated systematic review and meta-analysis.International wound journal · 2022Pooled it
- Gas Therapies for Chronic Wounds: Comparative Effectiveness, Safety, and Evidence Certainty-A Systematic Review and Network Meta-Analysis.Journal of clinical medicine · 2026Article
- Topical oxygen therapy and singlet oxygen in wound healing: A scoping review.International wound journal · 2024Article
- Article
- Recent Advances in Electrospun Nanofiber-Based Strategies for Diabetic Wound Healing Application.Pharmaceutics · 2023Review
- KADAM topical warm oxygen therapy device for diabetic foot ulcer-a novel approach.Journal of diabetes and metabolic disorders · 2023Article
- Ozone improved the wound healing in type 2 diabetics via down-regulation of IL- 8, 10 and induction of FGFR expression.Acta bio-medica : Atenei Parmensis · 2022Article
- Dynamic Role of Oxygen in Wound Healing: A Microbial, Immunological, and Biochemical Perspective.Archives of Razi Institute · 2022Review
- Topical Wound Oxygen Therapy in the Treatment of Chronic Diabetic Foot Ulcers.Medicina (Kaunas, Lithuania) · 2021Review
- The effect of continuous diffusion of oxygen treatment on cytokines, perfusion, bacterial load, and healing in patients with diabetic foot ulcers.International wound journal · 2020Article
- Editorial and Mini-Review: Topical Oxygen Therapy for Diabetic Foot Ulcerations - Avenue Towards New Hope?The review of diabetic studies : RDS · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIndividuals with diabetes may develop diabetic foot ulcers due to diabetic peripheral neuropathy. Multiple factors influence the ulcer healing process; oxygen helps in facilitating the different stages of wound healing.
objectiveThe objective of this systematic review was to analyze the different levels of evidence available in the application of topical oxygen therapy, warm oxygen therapy, or other modes of topical oxygen delivery in the healing dynamics of diabetic foot ulcers.
methodsDatabases searched included Pubmed/Medline, Science Direct, Web of Science, Scopus, Cochrane, and CINAHL. The eligibility criteria of studies included participants ≥18 years with chronic non-healing diabetic foot ulcer (duration ≥3 months) receiving warm oxygen or topical oxygen therapy (TOT), and other modes of topical oxygen administration, which were compared with standard care group. Randomized and non-randomized studies were included. The primary outcome measure assessed was the rate of wound healing or wound closure.
resultsThe review included 5 studies which used different modes of topical oxygen administration. The healing trajectory of the wounds was completely achieved in low-grade ulcers (grade 1), whereas all high-grade ulcers (grades 2, 3, and above) showed either 100% or 50% healing with a reduction in ulcer size and ulcer tissue depth.
conclusionTopical oxygen therapy facilitates wound healing dynamics among individuals with chronic diabetic foot ulcers.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.