ArticleJournal of acquired immune deficiency syndromes (1999)2020
Variations in HIV Risk by Young Women's Age and Partner Age Disparity in Rural South Africa (HPTN 068).
Article in Journal of acquired immune deficiency syndromes (1999), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 20 citations in OpenAlex.
- Patterns of Sexual Behaviors and Sexual Partner Characteristics as Predictors of Perceived HIV Risk and HIV Status Among Adolescent Girls and Young Women in Kenya.AIDS and behavior · 2026Article
- The age and sex dynamics of heterosexual HIV transmission in Zambia: an HPTN 071 (PopART) phylogenetic and modelling study.medRxiv : the preprint server for health sciences · 2026Article
- Factors associated with awareness of and willingness to use PrEP among stable, heterosexual HIV-serodifferent couples in seven African countries, 2019-2022.Journal of the International AIDS Society · 2025Article
- Transactional sex and age-disparate sexual partnerships among adolescent girls and young women in Tanzania.Frontiers in reproductive health · 2024Article
- Preferences, educational messaging, and demand creation channels for multipurpose-prevention technologies (MPTs) among women in South Africa.BMC public health · 2023Article
- Human papillomavirus prevalence in male and female university students in Gaborone, Botswana.Epidemiology and infection · 2022Article
- From Survival to Glamour: Motivations for Engaging in Transactional Sex and Relationships Among Adolescent Girls and Young Women in South Africa.AIDS and behavior · 2021Article
- 'Too old to test?': A life course approach to HIV-related risk and self-testing among midlife-older adults in Malawi.BMC public health · 2021Article
- Prevalence of Sexually Transmitted Infections and Factors Associated with HIV Status Among Vulnerable Women in Northern Uganda: Baseline Results from Pe Atye Kena Cohort Study.Mediterranean journal of hematology and infectious diseases · 2021Article
Corrections and comments
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Authors and funding
9 authors at 5 institutions in 4 countries.
Funding
Abstract
backgroundNearly all population-level research showing positive associations between age-disparate partnerships and HIV acquisition among adolescent girls and young women (AGYW) has classified age disparity as ≥5 or ≥10 years. We describe variations in 1-year risk of HIV infection after exposure to sexual partner(s) of continuous age disparities.
methodsLongitudinal data from the HPTN 068 randomized trial in South Africa were used to estimate 1-year risk of HIV infection at various age pairings. The parametric g-formula was used to estimate risk at up to 5 annual time points, stratified by maximum partner age difference, maximum partner age, and AGYW age.
resultsAGYW reported an older partner in 86% of 5351 age pairings. The 1-year risk of HIV infection rapidly increased with maximum partner age difference among girls ages 13-14 years, from 0·01 with a same-age partner, to 0·21 with a partner 10 years older, and 0·24 with a partner 15 years older. A gradual increase occurred among AGYW ages 15-16 years, up to 0·13 with a partner 15 years older, and 0·09 among AGYW 17-18 years with partners 8-11 years older. Risk of HIV infection among AGYW ages 19-21 years remained relatively constant across maximum partner age differences.
conclusionsAge differences between AGYW and their sexual partners have a greater effect on HIV-risk infection in younger compared with older AGYW. Considering both the age of an AGYW and her sexual partners provides granular insight into identifying key groups for HIV transmission prevention efforts.
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