ReviewCurrent opinion in clinical nutrition and metabolic care2020
Metabolic aspects of muscle wasting during critical illness.
Review in Current opinion in clinical nutrition and metabolic care, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 58 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
58 citing papers in PubMed, 3 syntheses or guidelines pooled it, 110 citations in OpenAlex.
- High-protein supplementation in critically ill patients: a systematic review, meta-analysis and umbrella review of existing evidence.Frontiers in nutrition · 2026Pooled it
- Gene Ontology (GO)-Driven Inference of Candidate Proteomic Markers Associated with Muscle Atrophy Conditions.Molecules (Basel, Switzerland) · 2022Pooled it
- The effect of higher versus lower protein delivery in critically ill patients: a systematic review and meta-analysis of randomized controlled trials.Critical care (London, England) · 2021Pooled it
- Combined intravenous bolus amino acid supplementation and mobilization on early muscle loss in critically ill adults: A randomized controlled trial.JPEN. Journal of parenteral and enteral nutrition · 2026Trial
- Impact of high-protein enteral nutrition on muscle preservation in mechanically ventilated patients with severe pneumonia: a randomized controlled trial.Journal of health, population, and nutrition · 2024Trial
- Deep learning-derived abdominal adiposity phenotypes and 28-day mortality in sepsis.International journal of obesity (2005) · 2026Article
- Pediatric post-intensive care malnutrition-risk factors and their association with long-term functional outcomes 1 year after discharge: a retrospective cohort study in Thailand.Acute and critical care · 2026Article
- Change in Nutritional Status of Children in the Pediatric Intensive Care Unit over First 14 Days: A Prospective Cohort Study.Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine · 2026Article
- Ultrasound assessment of muscle atrophy and its association with functional outcomes in critically ill patients: a systematic review and meta-analysis.Critical care (London, England) · 2026Review
- Skeletal Muscle Mass, Strength, and Functional Status in Critically Ill Older Adults Aged 60-75 and over 80 Years Old: An Exploratory Study.Healthcare (Basel, Switzerland) · 2026Article
- Protein nutritional support in critically ill patients: pathophysiological basis, clinical evidence, and areas of uncertainty - a narrative review.Frontiers in medicine · 2026Review
- Association between urea-to-creatinine ratio trajectories and clinical outcomes in chronic critical illness patients: a retrospective cohort study.Frontiers in nutrition · 2026Article
- Plasma creatine, estimated intramuscular creatine, transcellular gradient and the risk of mortality: Results from the PREVEND study.European journal of clinical investigation · 2026Article
- GNRI-stratified enteral nutrition protocol for elderly mechanically ventilated ICU patients: development and preliminary application.Frontiers in nutrition · 2026Article
- Ultrasonographic evaluation of quadriceps femoris muscle mass in critically ill patients aged 60 years and older: a prospective observational study.Frontiers in aging · 2026Article
- Muscle matters: Transforming the care of intensive care unit acquired sarcopenia and myosteatosis.World journal of clinical cases · 2025Review
- Effect of standard- versus high-protein enteral feeding on rectus femoris muscle mass in mechanically ventilated traumatic brain injury: prospective randomized study.Acute and critical care · 2025Article
- Differences in muscle atrophy between the lower limbs and the accessory respiratory muscles in critically ill patients.Journal of medical ultrasonics (2001) · 2025Article
- Body Composition Changes in Hospitalized Patients with Community-Acquired Pneumonia.Journal of clinical medicine · 2025Article
- Different trend of muscle wasting extracted from computed tomography in patients with severe acute pancreatitis.Abdominal radiology (New York) · 2025Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purpose of reviewSkeletal muscle wasting during critical illness is the result of disturbed metabolism. No proven effective interventions targeting skeletal muscle mass and function during critical illness currently exist. This review summarizes recent advances regarding the complexity of metabolic factors involved and the challenge of establishing the clinical effects of metabolic interventions targeting the muscle. RECENT
findingsAlthough the catabolic state is limited to the acute phase of critical illness, its subsequent impact on muscle mass and function persists long after ICU discharge. Immobilization, inflammation and disturbed muscle energy and nutrient metabolism are key drivers of muscle protein loss. Current research focuses on the effects of enhanced protein provision, specific substrate delivery and physical exercise. Whilst some interventions have been successful at improving muscle mass, these effects do not always carry over into muscle function or strength. SUMMARY: Increased understanding of metabolic derangements during critical illness provides new potential targets for treatment. The potential of dietary protein to attenuate the muscle protein catabolic state has yet to be established in clinical trials. Basic research should focus on ways to further improve the anabolic potential of nutrition by unravelling mechanisms that regulate anabolic and catabolic pathways and energy metabolism.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.