Evidence map›Paper›PMID 31904492›Full record

ArticleNeuroImage2020

The disengaging brain: Dynamic transitions from cognitive engagement and alcoholism risk.

Enrico Amico, Mario Dzemidzic, Brandon G Oberlin, Claire R Carron, Jaroslaw Harezlak, Joaquín Goñi, David A Kareken

Abstract read
In one paragraph

Article in NeuroImage, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

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  14. Behavioral processes and risk for problem substance use in adolescents.Pharmacology, biochemistry, and behavior · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Enrico AmicoPurdue Institute for Integrative Neuroscience, Purdue University, USA; School of Industrial Engineering, Purdue University, USA.
Mario DzemidzicDepartment of Neurology, Indiana University School of Medicine, Indiana Alcohol Research Center, USA.
Brandon G OberlinDepartment of Neurology, Indiana University School of Medicine, Indiana Alcohol Research Center, USA; Department of Psychiatry, Indiana University School of Medicine, USA.
Claire R CarronDepartment of Neurology, Indiana University School of Medicine, Indiana Alcohol Research Center, USA.
Jaroslaw HarezlakDepartment of Epidemiology and Biostatistics, Indiana University, USA.
Joaquín GoñiPurdue Institute for Integrative Neuroscience, Purdue University, USA; School of Industrial Engineering, Purdue University, USA; Weldon School of Biomedical Engineering, Purdue University, USA. Electronic address: jgonicor@purdue.edu.
David A KarekenDepartment of Neurology, Indiana University School of Medicine, Indiana Alcohol Research Center, USA. Electronic address: dkareken@iu.edu.

Funding

Translational Research and Science Education (OUT)P60AA007611 · NIAAA · INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS · PI Marian Lee Logrip · 2003 to 2026
$45.5M
Brain reward responses to sweet tastes in alcoholism riskR01AA022476 · NIAAA · INDIANA UNIVERSITY INDIANAPOLIS · PI KAREKEN, DAVID A. · 2014 to 2018
$2.8M
Alcohol-seeking behaviors and dopaminergic functionR01AA024588 · NIAAA · INDIANA UNIVERSITY INDIANAPOLIS · PI KAREKEN, DAVID A. · 2016 to 2020
$2.7M
Statistical models for multi-modal brain imaging studies of HIV-associated cognitive declineR01MH108467 · NIMH · INDIANA UNIVERSITY INDIANAPOLIS · PI HAREZLAK, JAROSLAW · 2015 to 2019
$2.0M
Integrative Bioinformatics Approaches to Human Brain Genomics and ConnectomicsR01EB022574 · NIBIB · UNIVERSITY OF PENNSYLVANIA · PI SHEN, LI · 2016 to 2019
$1.9M
Neural bases of alcohol-related decision-makingR00AA023296 · NIAAA · INDIANA UNIVERSITY INDIANAPOLIS · PI OBERLIN, BRANDON · 2017 to 2019
$747k
NIAAA NIH HHS P60 AA007611NIAAA NIH HHS R00 AA023296NIAAA NIH HHS R01 AA022476NIAAA NIH HHS R01 AA024588NIBIB NIH HHS R01 EB022574NIMH NIH HHS R01 MH108467
6 · The paper itself

Abstract

Human functional brain connectivity is usually measured either at "rest" or during cognitive tasks, ignoring life's moments of mental transition. We propose a different approach to understanding brain network transitions. We applied a novel independent component analysis of functional connectivity during motor inhibition (stop signal task) and during the continuous transition to an immediately ensuing rest. A functional network reconfiguration process emerged that: (i) was most prominent in those without familial alcoholism risk, (ii) encompassed brain areas engaged by the task, yet (iii) appeared only transiently after task cessation. The pattern was not present in a pre-task rest scan or in the remaining minutes of post-task rest. Finally, this transient network reconfiguration related to a key behavioral trait of addiction risk: reward delay discounting. These novel findings illustrate how dynamic brain functional reconfiguration during normally unstudied periods of cognitive transition might reflect addiction vulnerability, and potentially other forms of brain dysfunction.

Indexed as

ConnectomeGenetic Predisposition to DiseaseInhibition, PsychologicalRewardAdultAlcoholismCerebral CortexDelay DiscountingFemaleHumansMagnetic Resonance ImagingMaleMotor ActivityNerve NetTime FactorsYoung Adult

Identifiers

PMID31904492
PMCPMC8496455

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.